Stinco Giuseppe, Codutti Rolando, Scarbolo Marco, Valent Francesca, Patrone Pasquale
Department of Clinical and Experimental Pathology and Medicine, DPMSC Institute of Dermatology, University of Udine, 33013 Gemona del Friuli, Italy.
Acta Derm Venereol. 2005;85(2):136-9. doi: 10.1080/00015550410024481.
Bullous pemphigoid is a rare chronic recurrent dermatosis that is often reported in association with various neurological diseases. No investigation involving a large number of patients has ever been carried out to demonstrate such an association. This study was accomplished by analysing the discharge diagnosis of all hospitalized patients, both day-patients and inpatients, during a 5-year period (1995-2000) covering a total population group of 934,023 living in a region of Italy that has approximately 1,200,000 inhabitants. The results support the hypothesis of an association between bullous pemphigoid, multiple sclerosis and Parkinson's disease on a highly significant statistical basis. The aetiopathogenic mechanisms and the causes that induce the loss of immunological tolerance are not yet understood.
大疱性类天疱疮是一种罕见的慢性复发性皮肤病，常与各种神经系统疾病相关报道。从未进行过涉及大量患者的调查来证实这种关联。本研究通过分析1995年至2000年这5年期间所有住院患者（包括日间患者和住院患者）的出院诊断来完成，这些患者来自意大利一个约有120万居民的地区，总人口为934,023人。结果在高度显著的统计学基础上支持了大疱性类天疱疮、多发性硬化症和帕金森病之间存在关联的假设。免疫耐受丧失的发病机制和诱发原因尚不清楚。
