Taghipour Kathy, Chi Ching-Chi, Vincent Angela, Groves Richard W, Venning Vanessa, Wojnarowska Fenella
Department of Dermatology, Oxford Radcliffe Hospitals, Old Road, Headington, Oxford OX3 7LJ, England.
Arch Dermatol. 2010 Nov;146(11):1251-4. doi: 10.1001/archdermatol.2010.322.
To investigate the relationship between bullous pemphigoid (BP) and neurologic disease.
Case-control study.
Tertiary care center for immunobullous diseases and skin tumor clinics at a university hospital in Oxford, England.
Ninety consecutive patients with BP and 141 controls.
Age-adjusted prevalence of neurologic disease in patients and controls. Time interval between the diagnosis of neurologic disease and BP and type of associated neurologic disease.
At least 1 neurologic diagnosis was present in 42 patients (46%) compared with 16 controls (11%). Patients had significantly increased odds for neurologic diseases regardless of age and sex (crude odds ratio [OR], 6.8; 95% confidence interval [CI], 3.5-13.3; adjusted OR, 6.2; 95% CI, 3.1-12.4). Four major neurologic diagnoses were observed (cerebrovascular disease, dementia, Parkinson disease, and epilepsy), with statistical significance for cerebrovascular disease and dementia (crude OR for cerebrovascular disease, 6.3; 95% CI, 2.8-14.2; adjusted OR, 6.0; 95% CI, 2.6-13.6; crude OR for dementia, 10.7; 95% CI, 2.3-49.0; adjusted OR, 7.9; 95% CI, 1.7-37.3). When accurate data on time of onset of neurologic disease were present (36 of 42 patients [85%]), BP followed neurologic disease in most patients (26 of 36 patients [72%]), with a median interval of 5.5 years.
Bullous pemphigoid is significantly associated with cerebrovascular disease and dementia.
研究大疱性类天疱疮（BP）与神经系统疾病之间的关系。
病例对照研究。
英国牛津一家大学医院的免疫性大疱性疾病三级护理中心和皮肤肿瘤诊所。
90例连续的BP患者和141例对照。
患者和对照中神经系统疾病的年龄调整患病率。神经系统疾病诊断与BP之间的时间间隔以及相关神经系统疾病的类型。
42例患者（46%）至少有1项神经系统诊断，而对照中有16例（11%）。无论年龄和性别，患者患神经系统疾病的几率显著增加（粗比值比[OR]，6.8；95%置信区间[CI]，3.5 - 13.3；调整后OR，6.2；95% CI，3.1 - 12.4）。观察到4种主要的神经系统诊断（脑血管疾病、痴呆、帕金森病和癫痫），脑血管疾病和痴呆具有统计学意义（脑血管疾病的粗OR，6.3；95% CI，2.8 - 14.2；调整后OR，6.0；95% CI，2.6 - 13.6；痴呆的粗OR，10.7；95% CI，2.3 - 49.0；调整后OR，7.9；95% CI，1.7 - 37.3）。当有神经系统疾病发病时间的准确数据时（42例患者中的36例[85%]），大多数患者（36例患者中的26例[72%]）BP发生在神经系统疾病之后，中位间隔时间为5.5年。
大疱性类天疱疮与脑血管疾病和痴呆显著相关。
