Shiwaku Kuninori, Nogi Akiko, Kitajima Keiko, Anuurad Erdembileg, Enkhmaa Byambaa, Yamasaki Masayuki, Kim Jung-Man, Kim In-Shik, Lee Sung-Kook, Oyunsuren Tsendsuren, Yamane Yosuke
Department of Environmental and Preventive Medicine, Shimane University School of Medicine, 89-1 Enya-cho, Izumo City, Shimane 693-8501, Japan.
J Occup Health. 2005 Mar;47(2):126-35. doi: 10.1539/joh.47.126.
A clustering of insulin resistance, hypertension and dyslipidemia has been labeled as the metabolic syndrome. Asians have a lower frequency of obesity than do Caucasians, but have an increasing tendency toward metabolic syndrome. Most data on metabolic syndrome are based on studies from Western countries with only limited information derived from Asian populations. We conducted a cross-sectional study of individuals aged 30-60 yr in workplace settings. We examined and analyzed the health data of 1,384 Japanese, Koreans and Mongolians for metabolic syndrome based on the modified definitions of the working definition proposed by the Third Report of the National Cholesterol Educational Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III definition). The prevalence of metabolic syndrome using the ATP III-BMI30 and ATP III-BMI25 definitions was 7% and 12% for Japanese, 7% and 13% for Koreans, and 12% and 16% for Mongolians, respectively. With the exception of obesity, the prevalences of individual metabolic abnormalities within each of the three Asian groups were similar to each other and to reported rates of prevalence in the U.S.A. Nevertheless, the values of sensitivity and specificity by the metabolic syndrome definitions are remarkably different relative to ethnicity. A universal metabolic syndrome definition is inappropriate for comparisons of metabolic syndrome among Asian ethnic groups. We believe that the ATP III-BMI25 definition is suitable for the determination of metabolic syndrome among Japanese and Koreans, and that the ATP III-BMI30 is more appropriate for Mongolians.
胰岛素抵抗、高血压和血脂异常的聚集被称为代谢综合征。亚洲人的肥胖发生率低于白种人，但患代谢综合征的趋势却在增加。关于代谢综合征的大多数数据都来自西方国家的研究，而来自亚洲人群的信息有限。我们在工作场所对30至60岁的个体进行了一项横断面研究。我们根据美国国家胆固醇教育计划成人高血胆固醇检测、评估和治疗专家小组第三次报告（ATP III定义）提出的工作定义的修改定义，对1384名日本人、韩国人和蒙古人的健康数据进行了检查和分析，以确定代谢综合征。使用ATP III-BMI30和ATP III-BMI25定义时，日本人代谢综合征的患病率分别为7%和12%，韩国人分别为7%和13%，蒙古人分别为12%和16%。除肥胖外，三个亚洲组中各单项代谢异常的患病率彼此相似，且与美国报告的患病率相似。然而，代谢综合征定义的敏感性和特异性值因种族而异。通用的代谢综合征定义不适用于亚洲不同种族间代谢综合征的比较。我们认为，ATP III-BMI25定义适用于日本人及韩国人代谢综合征的判定，而ATP III-BMI30定义更适用于蒙古人。
