Alaei H, Esmaeili M, Nasimi A, Pourshanazari A
National Research Center of Medical Sciences, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Pathophysiology. 2005 Sep;12(2):103-7. doi: 10.1016/j.pathophys.2005.03.004.
Recent studies have indicated that the glutamatergic system is involved in the motivational aspects during the initiation of drug self-administration. Ascorbic acid (AA), an antioxidant vitamin, is released from glutamatergic neurons, and it modulates the synaptic action of dopamine and glutamate. In this study the AA effects on the self-administration of morphine and on the morphine withdrawal syndrome have been investigated. Wistar rats were allowed to self-administer morphine (1 mg/infusion) during 10 consecutive days for 2 h/session. The number of lever pressings was recorded. An intrapritoneal AA injection (500 mg/kg, i.p.), 30 min before morphine self-administration produced a significant decrease in the initiation of morphine self administration during all sessions. After the last test session morphine withdrawal symptom signs (MWS) were recorded after naloxone precipitation. Most of MWS (but not all) were decreased by AA application. In conclusion, AA may change the motivational processes underlying the morphine self-administration.
近期研究表明，谷氨酸能系统参与了药物自我给药起始阶段的动机方面。抗坏血酸（AA），一种抗氧化维生素，由谷氨酸能神经元释放，并且它调节多巴胺和谷氨酸的突触作用。在本研究中，已对AA对吗啡自我给药及吗啡戒断综合征的影响进行了研究。将Wistar大鼠连续10天每天2小时用于自我给药吗啡（1毫克/输注）。记录杠杆按压次数。在吗啡自我给药前30分钟腹腔注射AA（500毫克/千克，腹腔注射），在所有实验阶段均使吗啡自我给药的起始显著减少。在最后一次测试阶段后，在纳洛酮诱发后记录吗啡戒断症状体征（MWS）。AA应用使大多数（但并非全部）MWS减轻。总之，AA可能改变吗啡自我给药背后的动机过程。
