Källenius G, Koivula T, Rydgård K J, Hoffner S E, Valentin A, Asjö B, Ljungh C, Sharma U, Svenson S B
National Bacteriological Laboratory, Karolinska Institute, Stockholm, Sweden.
Infect Immun. 1992 Jun;60(6):2453-8. doi: 10.1128/iai.60.6.2453-2458.1992.
Disseminated Mycobacterium avium infections are common in patients with AIDS and result in a reduced life expectancy. Human monocytes/macrophages are important target cells for both human immunodeficiency virus (HIV) and M. avium. We have studied the interaction in vitro of M. avium and HIV type 1 (HIV-1) in human macrophages. Human monocytes isolated from the peripheral blood of healthy individuals were infected with HIV-1, M. avium, or both. The intracellular growth of M. avium and the replication of HIV-1 were monitored for up to 5 weeks. Intracellular mycobacterial growth was seen in all M. avium infected cell cultures and was paralleled by increased production of interleukin 1 alpha and beta. Preinfection of the macrophages with HIV-1 reduced the interleukin 1 production and accelerated the intracellular growth of M. avium. These findings may explain in part the impaired control of mycobacterial infections seen with patients with AIDS.
播散性鸟分枝杆菌感染在艾滋病患者中很常见，会导致预期寿命缩短。人单核细胞/巨噬细胞是人类免疫缺陷病毒（HIV）和鸟分枝杆菌的重要靶细胞。我们研究了鸟分枝杆菌与1型人类免疫缺陷病毒（HIV-1）在人巨噬细胞中的体外相互作用。从健康个体外周血中分离的人单核细胞感染了HIV-1、鸟分枝杆菌或两者。监测鸟分枝杆菌的细胞内生长和HIV-1的复制长达5周。在所有感染鸟分枝杆菌的细胞培养物中均可见细胞内分枝杆菌生长，同时白细胞介素1α和β的产生增加。HIV-1对巨噬细胞的预感染降低了白细胞介素1的产生，并加速了鸟分枝杆菌的细胞内生长。这些发现可能部分解释了艾滋病患者中分枝杆菌感染控制受损的情况。
