早期补体成分增强人血清对沙眼衣原体感染性的中和作用。
Early complement components enhance neutralization of Chlamydia trachomatis infectivity by human sera.
作者信息
Lin J S, Yan L L, Ho Y, Rice P A
机构信息
Maxwell Finland Laboratory, Boston City Hospital, Massachusetts.
出版信息
Infect Immun. 1992 Jun;60(6):2547-50. doi: 10.1128/iai.60.6.2547-2550.1992.
Abstract
Immunoglobulin G in human serum neutralizes chlamydial infectivity in vitro. Complement-intact, C5-depleted, and C8-depleted human serum all have significantly more neutralizing activity than serum heated to inactivate early components of complement. Cobra venom factor, an analog of human C3b, enhances neutralization of antichlamydial immunoglobulin G in the absence of early complement components.
摘要
人血清中的免疫球蛋白G在体外可中和衣原体感染性。补体完整、C5缺失和C8缺失的人血清均比加热灭活补体早期成分的血清具有显著更高的中和活性。眼镜蛇毒因子是人类C3b的类似物，在缺乏早期补体成分的情况下可增强抗衣原体免疫球蛋白G的中和作用。
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