Delzenne Nathalie M, Cani Patrice D, Daubioul Catherine, Neyrinck Audrey M
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, MD/FARM/PMNT 7369, Université Catholique de Louvain, Avenue E Mounier 73, B-1200 Brussels, Belgium.
Br J Nutr. 2005 Apr;93 Suppl 1:S157-61. doi: 10.1079/bjn20041342.
In the present paper, we summarise the data supporting the following hypothesis: dietary inulin-type fructans extracted from chicory root may modulate the production of peptides, such as incretins, by endocrine cells present in the intestinal mucosa, this phenomenon being involved in the regulation of food intake and/or systemic effects. To test this hypothesis, male Wistar rats received for 3 weeks either a standard diet or the same diet supplemented with 10 % inulin-type fructans with different degrees of polymerisation. All the effects were most pronounced with the diet containing oligofructose, and consisted of (i) a decrease in mean daily energy intake and in epididymal fat mass; (ii) a higher caecal pool of the anorexigenic glucagon-like peptide-1 (7-36) amide (GLP-1), and peptide YY (PYY), due to caecal tissue proliferation; (iii) an increase in GLP-1 and of its precursor - proglucagon mRNA - concentrations in the proximal colon; (iv) an increase in portal serum level of GLP-1 and PYY; (v) a decrease in serum orexigenic peptide ghrelin. Moreover, oligofructose supplementation improved glucose homeostasis (i.e. decreased glycaemia, increased pancreatic and serum insulin content) in diabetic rats previously treated with streptozotocin, a phenomenon that is partly linked to the reduction in food intake and that correlates with the increase in colic and portal GLP-1 content. Based on these results it appears justified to test, in human subjects, the hypothesis that dietary inulin-type fructans could play a role in the management of obesity and diabetes through their capacity to promote secretion of endogenous gastrointestinal peptides involved in appetite regulation.
在本论文中，我们总结了支持以下假设的数据：从菊苣根中提取的膳食菊粉型果聚糖可能调节肠道黏膜中内分泌细胞产生肽类，如肠促胰岛素，这一现象参与食物摄入调节和/或全身效应。为验证这一假设，雄性Wistar大鼠连续3周分别喂食标准饮食或添加10%不同聚合度菊粉型果聚糖的相同饮食。含低聚果糖的饮食产生的所有效应最为显著，包括：（i）平均每日能量摄入和附睾脂肪量减少；（ii）由于盲肠组织增殖，厌食性胰高血糖素样肽-1（7-36）酰胺（GLP-1）和肽YY（PYY）的盲肠池增加；（iii）近端结肠中GLP-1及其前体——胰高血糖素原mRNA的浓度增加；（iv）门静脉血清中GLP-1和PYY水平升高；（v）血清促食欲肽胃饥饿素降低。此外，补充低聚果糖改善了先前用链脲佐菌素治疗的糖尿病大鼠的葡萄糖稳态（即血糖降低、胰腺和血清胰岛素含量增加），这一现象部分与食物摄入量减少有关，且与结肠和门静脉GLP-1含量增加相关。基于这些结果，在人类受试者中检验膳食菊粉型果聚糖通过促进参与食欲调节的内源性胃肠肽分泌而在肥胖和糖尿病管理中发挥作用这一假设似乎是合理的。
