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肠道常驻微生物群落决定了可溶性纤维在减轻肥胖方面的功效。

Resident gut microbiota community determines the efficacy of soluble fiber in reducing adiposity.

作者信息

Shallangwa Swang M, Ross Alexander W, Walker Alan W, Morgan Peter J

机构信息

Rowett Institute, University of Aberdeen, Scotland, United Kingdom.

出版信息

Front Microbiol. 2024 Apr 30;15:1392016. doi: 10.3389/fmicb.2024.1392016. eCollection 2024.

DOI:10.3389/fmicb.2024.1392016
PMID:38746744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11091261/
Abstract

Consumption of dietary fiber has been linked to several health benefits. Among these, dietary fiber breakdown through the process of anaerobic fermentation by the colonic microbiota leads to the production of beneficial metabolites, mainly short-chain fatty acids (acetate, propionate, and butyrate), which have been implicated in reduced calorie intake. Nevertheless, the link between gut microbiota and obesity remains unclear. We investigated the effects of dietary fibers on food intake and body weight gain in two independent but similarly designed studies in rats. In the first study, the inclusion of 10% w/w pectin, fructooligosaccharides or beta-glucan ( = 10/group) in the diets each significantly reduced body weight gain () compared to the cellulose control whereas, in a closely matched, but not fully identical study ( = 8/group), no effect of dietary fiber on body weight () was observed. The aim of this work was to explore the basis of this differential response between the two similarly designed and comparable studies, with a focus on the potential role of the gut microbiota in the control of food intake and body weight.

摘要

膳食纤维的摄入与多种健康益处相关。其中，结肠微生物群通过厌氧发酵过程分解膳食纤维会产生有益代谢物，主要是短链脂肪酸（乙酸、丙酸和丁酸），这些物质与减少热量摄入有关。然而，肠道微生物群与肥胖之间的联系仍不明确。我们在两项独立但设计相似的大鼠研究中，研究了膳食纤维对食物摄入量和体重增加的影响。在第一项研究中，与纤维素对照组相比，饮食中包含10% w/w的果胶、低聚果糖或β-葡聚糖（每组 = 10只）均显著降低了体重增加（）；而在一项密切匹配但不完全相同的研究（每组 = 8只）中，未观察到膳食纤维对体重（）的影响。这项工作的目的是探究这两项设计相似且具有可比性的研究之间这种差异反应的基础，重点关注肠道微生物群在控制食物摄入量和体重方面的潜在作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/16938119c84f/fmicb-15-1392016-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/3a167f81823d/fmicb-15-1392016-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/d2fe9c126e2e/fmicb-15-1392016-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/05988b896465/fmicb-15-1392016-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/16938119c84f/fmicb-15-1392016-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/9a6b4492bfaa/fmicb-15-1392016-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/e7eb4ecd5055/fmicb-15-1392016-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/7677b9529086/fmicb-15-1392016-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/04d03505e693/fmicb-15-1392016-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/3a167f81823d/fmicb-15-1392016-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/d2fe9c126e2e/fmicb-15-1392016-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/05988b896465/fmicb-15-1392016-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0194/11091261/16938119c84f/fmicb-15-1392016-g008.jpg

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