Logan Nicola, Graham Anne, Zhao Xuijie, Fisher Rebecca, Maiti Baidehi, Leone Gustavo, La Thangue Nicholas B
Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK.
Oncogene. 2005 Jul 21;24(31):5000-4. doi: 10.1038/sj.onc.1208703.
E2F is a family of transcription factors implicated in cell cycle control. To understand the role of E2F in controlling cell cycle progression, it is necessary to clarify the breadth of the E2F family. To date, seven E2F subunits have been identified. We report here the characterization of a new E2F subunit, E2F-8, which resembles the organization of E2F-7 in the presence of two separate DNA-binding domains, the integrity of which is required for E2F-8 to bind to DNA. Furthermore, like E2F-7, we find that E2F-8 can repress transcription and delay cell cycle progression. The similarities between E2F-7 and E2F-8 define a new subgroup of the E2F family, and further imply that E2F-7 and E2F-8 may act through overlapping mechanisms in mediating cell cycle control.
E2F是一族与细胞周期调控相关的转录因子。为了解E2F在控制细胞周期进程中的作用，有必要阐明E2F家族的范围。迄今为止，已鉴定出7种E2F亚基。我们在此报告一种新的E2F亚基E2F-8的特征，它在存在两个独立的DNA结合结构域时类似于E2F-7的结构，E2F-8与DNA结合需要这两个结构域的完整性。此外，与E2F-7一样，我们发现E2F-8可以抑制转录并延迟细胞周期进程。E2F-7和E2F-8之间的相似性定义了E2F家族的一个新亚组，进一步表明E2F-7和E2F-8可能通过重叠机制介导细胞周期调控。
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