Webster Guy
Department of Dermatology, Jefferson Medical College, Philadelphia, PA 19107, USA.
J Drugs Dermatol. 2005 May-Jun;4(3):281-8.
Acne vulgaris has multiple pathogenic mechanisms that act in concert to produce disease. Effective therapy addresses more than one pathogenic factor to speed resolution of disease. Typically, retinoids are used to inhibit comedo formation and an antibacterial is used to suppress Propionibacterium acnes (P. acnes). Using combinations of agents can enhance efficacy, but increase side effects. Therefore, the tolerability of a topical retinoid is important. Strategies to enhance retinoid tolerability include the use of new retinoids such as adapalene, new delivery systems such as the tretinoin microsphere delivery system, or alternative dosing schedules such as short contact or every other day (QOD).
寻常痤疮有多种致病机制，这些机制共同作用导致疾病发生。有效的治疗需要针对不止一个致病因素，以加速疾病的消退。通常，维甲酸类药物用于抑制粉刺形成，抗菌药物用于抑制痤疮丙酸杆菌（P. acnes）。联合使用多种药物可提高疗效，但会增加副作用。因此，局部用维甲酸类药物的耐受性很重要。提高维甲酸类药物耐受性的策略包括使用新的维甲酸类药物如阿达帕林、新的给药系统如维甲酸微球给药系统，或采用替代给药方案如短接触或隔日（QOD）给药。
