来自昆虫病原真菌半翅小轮枝菌BCC 1449的独特二酮哌嗪二聚体。

Unique diketopiperazine dimers from the insect pathogenic fungus Verticillium hemipterigenum BCC 1449.

作者信息

Isaka Masahiko, Palasarn Somporn, Rachtawee Pranee, Vimuttipong Saovaluk, Kongsaeree Palangpon

机构信息

National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, 113 Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.

出版信息

Org Lett. 2005 May 26;7(11):2257-60. doi: 10.1021/ol0507266.

DOI:10.1021/ol0507266

PMID:15901183

Abstract

[structure: see text]. Vertihemiptellides A (1) and B (2), unique diketopiperazine dimers, were isolated from the insect pathogenic fungus Verticillium hemipterigenum BCC 1449. Structures of these compounds were elucidated by NMR and mass spectral analysis, and the stereochemistry of 1 was determined by X-ray crystallography. The absolute stereochemistry of bisdethiodi(methylthio)-1-demethylhyalodendrin (3), previously isolated from the same fungus, was revised to the (3R,6R) configuration.

摘要

[结构：见正文]。从昆虫病原真菌半翅生轮枝菌BCC 1449中分离得到了独特的二酮哌嗪二聚体——半翅生轮枝菌素A（1）和B（2）。通过核磁共振（NMR）和质谱分析阐明了这些化合物的结构，并通过X射线晶体学确定了1的立体化学。先前从同一真菌中分离得到的双去硫代二（甲硫基）-1-去甲基透明枝菌素（3）的绝对立体化学被修正为（3R，6R）构型。