Kaprio J, Viken R, Koskenvuo M, Romanov K, Rose R J
Department of Public Health, University of Helsinki, Finland.
Alcohol Clin Exp Res. 1992 Apr;16(2):234-40. doi: 10.1111/j.1530-0277.1992.tb01369.x.
In 1975 and again in 1981, all adult twins in the population-based Finnish Twin Cohort were administered postal questionnaires yielding data on self-reported frequency and quantity of alcohol use. The longitudinal results provide information on the age-to-age stability of social drinking patterns among 13,404 (twin) individuals aged 18 to 43 at baseline; model-fitting the cross-temporal consistency of the twins' reported alcohol use yields unique estimates of the contribution of genetic and environmental factors to their individual age-to-age stabilities. Mean consumption levels did not change between 1975 and 1981. Patterns of social drinking were more stable in older (aged 24-43 at baseline) than younger (aged 18-23 at baseline) adult twins, and were more stable among men than women. Heritabilities were significant at both baseline and follow-up for all three alcohol measures in both genders and both age groups, with a median magnitude of 0.48. Both longitudinal genetic and environmental covariances were significant, and both were generally higher among older pairs. Genetic covariances (median magnitude = 0.68) were significantly higher than environmental covariances (median = 0.36). Analyses of absolute changes in alcohol use revealed heritable influences on the disposition to change. We conclude that genes contribute to both consistency and change in patterns of alcohol use from early to midadulthood.
1975年和1981年,基于芬兰全国人口的双胞胎队列中的所有成年双胞胎都收到了邮寄问卷,这些问卷提供了关于自我报告的饮酒频率和饮酒量的数据。纵向研究结果提供了有关13404名(双胞胎)个体(基线年龄为18至43岁)社会饮酒模式随年龄变化稳定性的信息;对双胞胎报告的饮酒情况进行跨时间一致性的模型拟合,得出了遗传和环境因素对其个体年龄变化稳定性贡献的独特估计值。1975年至1981年间,平均饮酒水平没有变化。在年龄较大(基线年龄为24至43岁)的成年双胞胎中,社会饮酒模式比年龄较小(基线年龄为18至23岁)的成年双胞胎更稳定,并且在男性中比在女性中更稳定。对于两个性别和两个年龄组的所有三项酒精测量指标,遗传力在基线和随访时均具有显著性,中位数为0.48。纵向遗传协方差和环境协方差均具有显著性,并且在年龄较大的双胞胎对中通常更高。遗传协方差(中位数为0.68)显著高于环境协方差(中位数为0.36)。对饮酒绝对变化的分析揭示了遗传因素对变化倾向的影响。我们得出结论,基因在从成年早期到成年中期的饮酒模式一致性和变化中都发挥作用。