氯喹与氯丙嗪或奋乃静联合使用对恶性疟原虫分离株的体外活性。
In vitro activities of chloroquine in combination with chlorpromazine or prochlorperazine against isolates of Plasmodium falciparum.
作者信息
Basco L K, Le Bras J
机构信息
Centre National de Référence pour la Chimiosensibilité du Paludisme, Hôpital Bichat-Claude Bernard, Paris, France.
出版信息
Antimicrob Agents Chemother. 1992 Jan;36(1):209-13. doi: 10.1128/AAC.36.1.209.
Abstract
The combinations of chloroquine plus chlorpromazine and chloroquine plus prochlorperazine were evaluated in vitro for potentiation against isolates of Plasmodium falciparum. Potentiation was observed against all chloroquine-resistant isolates. There was no potentiation against 8 of 10 chloroquine-susceptible isolates. The results indicated that the phenothiazines can potentiate chloroquine action against resistant parasites found in natural conditions.
摘要
对氯喹加氯丙嗪以及氯喹加奋乃静的组合进行了体外评估，以检测其对恶性疟原虫分离株的增效作用。观察到对所有耐氯喹分离株均有增效作用。对10株氯喹敏感分离株中的8株没有增效作用。结果表明，吩噻嗪类药物可增强氯喹对在自然条件下发现的耐药寄生虫的作用。
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本文引用的文献
1
In vitro study of drug sensitivity of Plasmodium falciparum: evaluation of a new semi-micro test.恶性疟原虫药物敏感性的体外研究：一种新的半微量试验的评估
Am J Trop Med Hyg. 1983 May;32(3):447-51. doi: 10.4269/ajtmh.1983.32.447.
2
Reversal of chloroquine resistance in Plasmodium falciparum by verapamil.维拉帕米逆转恶性疟原虫对氯喹的耐药性。
Science. 1987 Feb 20;235(4791):899-901. doi: 10.1126/science.3544220.
3
Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.地昔帕明逆转恶性疟原虫对氯喹的耐药性。
Science. 1988 Dec 2;242(4883):1301-3. doi: 10.1126/science.3057629.
4
Plasma level monitoring of antipsychotic drugs. Clinical utility.抗精神病药物的血药浓度监测。临床应用。
Clin Pharmacokinet. 1986 Jan-Feb;11(1):36-61. doi: 10.2165/00003088-198611010-00003.
5
Antihistaminic drugs that reverse chloroquine resistance in Plasmodium falciparum.可逆转恶性疟原虫对氯喹耐药性的抗组胺药物。
Lancet. 1989 Aug 5;2(8658):334-5. doi: 10.1016/s0140-6736(89)90522-9.
6
Tricyclic antidepressant plasma level monitoring: intraindividual variability in everyday practice.三环类抗抑郁药血浆水平监测：日常实践中的个体内变异性
Eur J Clin Pharmacol. 1990;39(6):611-2. doi: 10.1007/BF00316109.
7
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Trans R Soc Trop Med Hyg. 1990 Jul-Aug;84(4):479-81. doi: 10.1016/0035-9203(90)90006-z.
8
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Trans R Soc Trop Med Hyg. 1990 Jul-Aug;84(4):474-8. doi: 10.1016/0035-9203(90)90004-x.
9
Field study of cyproheptadine/chloroquine synergism in falciparum malaria.赛庚啶/氯喹对恶性疟协同作用的现场研究
Lancet. 1990 Jul 7;336(8706):59-60. doi: 10.1016/0140-6736(90)91579-y.
10
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Trans R Soc Trop Med Hyg. 1991 Mar-Apr;85(2):204-5. doi: 10.1016/0035-9203(91)90019-u.
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