Vanstraelen P
Department of Plastic Surgery, Charing Cross Hospital, London, UK.
Burns. 1992 Apr;18(2):145-8. doi: 10.1016/0305-4179(92)90014-l.
In a controlled, prospective study, calcium sodium alginate and porcine xenograft were compared in the treatment of split-thickness skin graft donor sites on 20 patients. Half of each donor site was dressed with each material. Time to complete healing, quality of regenerated skin and patient comfort were assessed. Time to healing was 8.1 days with alginate and 11.3 days with porcine xenograft (P less than 0.001). Quality of healed skin was consistently good with the alginate, and better than under the xenograft in 95 per cent of patients (P less than 0.001). Hypertrophic scarring was not observed under alginate dressings but occurred in 25 per cent of xenograft-dressed sites (P less than 0.01). In addition, evidence was found that allergic reactions to porcine xenograft could occur. Alginate was preferred by 75 per cent of patients and none preferred porcine xenograft (P less than 0.01); the remainder had no preference. It was concluded that porcine xenograft is inferior to calcium sodium alginate as a dressing for split-thickness skin donor sites.
在一项对照前瞻性研究中，对20例患者的中厚皮片供皮区，比较了藻酸钙钠敷料与猪异种移植物敷料的效果。每个供皮区的一半用每种材料进行包扎。评估愈合所需时间、再生皮肤质量和患者舒适度。使用藻酸钙钠敷料时愈合时间为8.1天，使用猪异种移植物时为11.3天（P<0.001）。使用藻酸钙钠敷料时，愈合皮肤质量始终良好，95%的患者其愈合皮肤质量优于使用异种移植物者（P<0.001）。藻酸钙钠敷料下未观察到增生性瘢痕形成，但在使用异种移植物包扎的部位有25%出现了增生性瘢痕（P<0.01）。此外，发现有证据表明可能会发生对猪异种移植物的过敏反应。75%的患者更喜欢藻酸钙钠敷料，无人更喜欢猪异种移植物（P<0.01）；其余患者没有偏好。得出的结论是，作为中厚皮片供皮区的敷料，猪异种移植物不如藻酸钙钠。
