一种用于测量酿酒酵母中所有可能碱基对替换的新回复突变检测法。
A new reversion assay for measuring all possible base pair substitutions in Saccharomyces cerevisiae.
作者信息
Williams Teresa-Marie, Fabbri Rebecca M, Reeves Jason W, Crouse Gray F
机构信息
Department of Biology, Emory University, Atlanta, Georgia 30322, USA.
出版信息
Genetics. 2005 Jul;170(3):1423-6. doi: 10.1534/genetics.105.042697. Epub 2005 May 23.
Abstract
A TRP5-based reversion system that allows the rates of all possible base pair substitutions to be measured when the TRP5 locus is in both orientations relative to a defined origin of replication has been developed. This system should be useful for a wide variety of mutation and repair studies in yeast.
摘要
已经开发出一种基于TRP5的回复系统，当TRP5基因座相对于一个确定的复制起点处于两种方向时，该系统能够测量所有可能的碱基对替换率。该系统对于酵母中各种各样的突变和修复研究应该是有用的。
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