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一种用于测量酿酒酵母中所有可能碱基对替换的新回复突变检测法。

A new reversion assay for measuring all possible base pair substitutions in Saccharomyces cerevisiae.

作者信息

Williams Teresa-Marie, Fabbri Rebecca M, Reeves Jason W, Crouse Gray F

机构信息

Department of Biology, Emory University, Atlanta, Georgia 30322, USA.

出版信息

Genetics. 2005 Jul;170(3):1423-6. doi: 10.1534/genetics.105.042697. Epub 2005 May 23.

DOI:10.1534/genetics.105.042697
PMID:15911571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1451166/
Abstract

A TRP5-based reversion system that allows the rates of all possible base pair substitutions to be measured when the TRP5 locus is in both orientations relative to a defined origin of replication has been developed. This system should be useful for a wide variety of mutation and repair studies in yeast.

摘要

已经开发出一种基于TRP5的回复系统，当TRP5基因座相对于一个确定的复制起点处于两种方向时，该系统能够测量所有可能的碱基对替换率。该系统对于酵母中各种各样的突变和修复研究应该是有用的。

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本文引用的文献

1
Targeted nucleotide repair of cyc1 mutations in Saccharomyces cerevisiae directed by modified single-stranded DNA oligonucleotides.经修饰的单链DNA寡核苷酸介导的酿酒酵母中cyc1突变的靶向核苷酸修复
Genetics. 2003 Feb;163(2):527-38. doi: 10.1093/genetics/163.2.527.
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Yeast origins establish a strand bias for replicational mutagenesis.酵母起源为复制性诱变建立了链偏向性。
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Deletion of the MAG1 DNA glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleases.MAG1 DNA 糖基化酶基因的缺失可抑制缺乏 AP 内切核酸酶的酵母细胞中烷基化诱导的杀伤和诱变作用。
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Completion of replication map of Saccharomyces cerevisiae chromosome III.酿酒酵母三号染色体复制图谱绘制完成。
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In vivo site-directed mutagenesis using oligonucleotides.使用寡核苷酸进行体内定点诱变。
Nat Biotechnol. 2001 Aug;19(8):773-6. doi: 10.1038/90837.
6
Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the LYS2 gene of yeast Saccharomyces cerevisiae.酵母酿酒酵母LYS2基因中碱基类似物6-N-羟基氨基嘌呤的诱变特异性。
Mutat Res. 2001 Feb 20;473(2):151-61. doi: 10.1016/s0027-5107(00)00142-1.
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