Erickson Kirk I, Colcombe Stanley J, Raz Naftali, Korol Donna L, Scalf Paige, Webb Andrew, Cohen Neal J, McAuley Edward, Kramer Arthur F
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 61801, USA.
Neurobiol Aging. 2005 Aug-Sep;26(8):1205-13. doi: 10.1016/j.neurobiolaging.2004.11.009. Epub 2005 Jan 7.
Determining the benefits and/or drawbacks of hormone replacement therapy (HRT) on women's health is an imperative public health goal. Research in rodents suggests benefits of estrogen on neuronal growth and function. However, little research has investigated the effects of HRT on brain tissue in humans. We used high-resolution magnetic resonance imaging and an optimized voxel-based morphometric technique to examine the effects of HRT on brain volume in postmenopausal women. We report two main results: (a) HRT is associated with the sparing of grey matter in prefrontal, parietal, and temporal brain regions and white matter in medial temporal lobe regions, and (b) longer durations of therapy are associated with greater sparing of grey matter tissue. HRT should be considered a possible mediator of age-related neural decline in both grey and white matter tissues.
确定激素替代疗法（HRT）对女性健康的益处和/或弊端是一项紧迫的公共卫生目标。对啮齿动物的研究表明雌激素对神经元生长和功能有益。然而，很少有研究调查HRT对人体脑组织的影响。我们使用高分辨率磁共振成像和优化的基于体素的形态测量技术来研究HRT对绝经后女性脑容量的影响。我们报告了两个主要结果：（a）HRT与前额叶、顶叶和颞叶脑区灰质以及内侧颞叶区域白质的保留有关，（b）治疗时间越长，灰质组织的保留程度越高。HRT应被视为灰质和白质组织中与年龄相关神经衰退的可能调节因素。
