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两性霉素B和伏立康唑对土曲霉粉孢子的体外活性。

In vitro activities of amphotericin B and voriconazole against aleurioconidia from Aspergillus terreus.

作者信息

Lass-Flörl Cornelia, Rief Alexandra, Leitner Sandra, Speth Cornelia, Würzner Reinhard, Dierich Manfred P

机构信息

Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Str. 3/III, Innsbruck 6020, Austria.

出版信息

Antimicrob Agents Chemother. 2005 Jun;49(6):2539-40. doi: 10.1128/AAC.49.6.2539-2540.2005.

DOI:10.1128/AAC.49.6.2539-2540.2005
PMID:15917567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1140531/
Abstract

This study used aleurioconidia as inoculum and compared the MICs of amphotericin B and voriconazole to those obtained for conidia of 31 Aspergillus terreus strains. For conidia and aleurioconidia, the MIC at which 90% of strains were inhibited was 2.5 microg/ml and 5 microg/ml with amphotericin B and 1 microg/ml and 2 microg/ml with voriconazole.

摘要

本研究使用粉孢子作为接种物，并比较了两性霉素B和伏立康唑对31株土曲霉分生孢子的最低抑菌浓度（MIC）。对于分生孢子和粉孢子，两性霉素B抑制90%菌株生长的MIC分别为2.5微克/毫升和5微克/毫升，伏立康唑的分别为1微克/毫升和2微克/毫升。

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