Cota Jason M, Grabinski Jodi L, Talbert Robert L, Burgess David S, Rogers P David, Edlind Thomas D, Wiederhold Nathan P
University of Texas at Austin College of Pharmacy, UTHSCSA, PERC MSC 6220, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Antimicrob Agents Chemother. 2008 Mar;52(3):1144-6. doi: 10.1128/AAC.01542-07. Epub 2007 Dec 17.
Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Delta slt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.
观察到卡泊芬净对光滑念珠菌存在不完全杀灭情况,这与SLT2表达增加和几丁质含量升高有关。相比之下,在同基因的Δslt2菌株中观察到杀菌活性且几丁质没有增加,这表明SLT2和几丁质产生在光滑念珠菌对卡泊芬净的反应中起作用。