Mougin F, Simon-Rigaud M L, Mougin C, Bourdin H, Jacquier M C, Henriet M T, Davenne D, Kantelip J P, Magnin P, Gaillard R C
Service de Physiopathologie Respiratoire et Cérébrale, Médecine et Biologie du Sport, CHU F-25030 Besançon, France.
Eur J Appl Physiol Occup Physiol. 1992;64(4):371-6. doi: 10.1007/BF00636226.
The present study compared the effects of partial sleep deprivation and the effects of an intake of a hypnotic compound (zolpidem) prior to bedtime, on sleep and on hormonal and metabolic adaptations to subsequent exercise. Sleep deprivation consisted of a delayed bedtime and an early getting-up time. Eight young subjects, who slept well and were highly trained athletes, were enrolled in this study. Sleep was recorded polygraphically and the following afternoon exercise was performed on a cycle ergometer for 30 min at 75% of maximal oxygen consumption (VO2max) after a 10-min warm up. Met-enkephalin, beta-endorphin, cortisol, and lactate concentrations were measured at rest and during exercise. The data obtained after experimental sleep, with and without medication were compared with those obtained in the reference condition with normal sleep. Both types of sleep reduction decreased the total sleep time, stage 2 sleep, and rapid eye movement sleep, whereas zolpidem administration did not modify either the duration of sleep or the sleep stages. After the reference night, plasma met-enkephalin did not show any significant change at the end of the submaximal exercise, whereas beta-endorphin, cortisol, and lactic acid concentrations increased significantly in all subjects. The changes in concentration in beta-endorphin were significantly related to the changes in cortisol (r = 0.78; P less than 0.01) and to the changes in plasma lactic acid (r = 0.58; P less than 0.05). Cortisol concentrations were also related to lactic acid values (r = 0.94; P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
本研究比较了部分睡眠剥夺以及睡前摄入催眠化合物（唑吡坦）对睡眠、激素和后续运动代谢适应的影响。睡眠剥夺包括延迟就寝时间和提前起床时间。八名睡眠良好且训练有素的年轻运动员参与了本研究。通过多导睡眠图记录睡眠情况，次日下午，在进行10分钟热身运动后，受试者在自行车测力计上以最大耗氧量（VO2max）的75%进行30分钟运动。在休息和运动期间测量甲硫氨酸脑啡肽、β-内啡肽、皮质醇和乳酸浓度。将有用药和无用药的实验性睡眠后获得的数据与正常睡眠参考条件下获得的数据进行比较。两种类型的睡眠减少均降低了总睡眠时间、2期睡眠和快速眼动睡眠，而服用唑吡坦既未改变睡眠时间也未改变睡眠阶段。在参考夜晚后，次最大运动结束时血浆甲硫氨酸脑啡肽未显示任何显著变化，而所有受试者的β-内啡肽、皮质醇和乳酸浓度均显著增加。β-内啡肽浓度变化与皮质醇变化显著相关（r = 0.78；P < 0.01），与血浆乳酸变化也显著相关（r = 0.58；P < 0.05）。皮质醇浓度也与乳酸值相关（r = 0.94；P < 0.01）。（摘要截断于250字）
