Spinillo A, Carratta L, Pizzoli G, Lombardi G, Cavanna C, Michelone G, Guaschino S
Department of Obstetrics and Gynecology, University of Pavia, Italy.
J Reprod Med. 1992 Apr;37(4):343-7.
Yeast cultures from the oral cavity, vagina and rectum were obtained from 125 women experiencing an acute episode of recurrent candidal vaginitis. To investigate the role of sexual transmission, oral, penile and ejaculate cultures were also prepared from all the male sexual partners. The rates of oral and rectal Candida species colonization in the women were 36% (45/125) and 44.8% (56/125), respectively. The male partners' oral cavities were positive in 23.2% (29/125) and the penile coronal sulcus and seminal fluid in 16% (20/125) and 14.4% (18/125), respectively. The susceptibility of the isolated species to the main antimycotic drugs was ascertained with the agar diffusion method. Therapy in the women and the colonized sexual partners was carried out, eliminating the microorganism from every positive site. Control cultures were obtained two weeks after the completion of therapy, and follow-up was continued for one year. The overall clinical and microbiologic cure rate in the study group was 72% (95/125). The rate of relapse was not influenced by the treatment of Candida colonization of the female intestinal tract. The recurrence rate after treatment in the couples in which the man harbored yeast (oral cavity, penile coronal sulcus, seminal fluid) was lower (15.8% vs. 44.8%, P = .0019) than that recorded in the couples without sexual partner involvement. The identification and treatment of the male sexual partner's Candida colonization seems important in the prevention of recurrent vulvovaginitis.
从125名复发性念珠菌性阴道炎急性发作的女性患者中获取口腔、阴道和直肠的酵母培养物。为了研究性传播的作用，还从所有男性性伴侣处采集了口腔、阴茎和精液培养物。女性口腔和直肠念珠菌属定植率分别为36%（45/125）和44.8%（56/125）。男性伴侣口腔阳性率为23.2%（29/125），阴茎冠状沟和精液阳性率分别为16%（20/125）和14.4%（18/125）。采用琼脂扩散法确定分离菌株对主要抗真菌药物的敏感性。对女性患者及其定植的性伴侣进行治疗，清除每个阳性部位的微生物。治疗结束两周后获取对照培养物，并持续随访一年。研究组的总体临床和微生物学治愈率为72%（95/125）。念珠菌性女性肠道定植的治疗对复发率没有影响。男性携带酵母菌（口腔、阴茎冠状沟、精液）的夫妇治疗后的复发率较低（15.8%对44.8%，P = 0.0019），低于无性伴侣参与的夫妇。男性性伴侣念珠菌定植的鉴定和治疗对于预防复发性外阴阴道炎似乎很重要。
