Tarkun Ilhan, Hacihanefioğlu Abdullah, Tarkun Pinar, Cetinarslan Berrin, Cantürk Zeynep
Endocrinology and Metabolism, Kocaeli University, Kocaeli, Turkey.
Diabetes Res Clin Pract. 2005 Jun;68(3):181-7. doi: 10.1016/j.diabres.2004.09.005.
Anticardiolipin and anti-beta2 glycoprotein I antibodies are associated with an increased tendency to thrombosis by various mechanisms. This study aimed to evaluate the association between micro and macrovascular complications of diabetes and anticardiolipin and anti-beta2 glycoprotein I antibodies. Forty-six patients with type 2 diabetes mellitus (T2DM) were studied. Twenty-one patients had coronary artery disease as a macrovascular complication. Twenty-five age and sex matched healthy subjects formed a control group. Anticardiolipin IgM, IgG, anti-beta2 glycoprotein IgM and IgG antibody levels were studied in both patient and control groups. Diabetic patients with ischaemic heart disease had significantly higher titres of anticardiolipin IgG antibody than patients without ischaemic heart disease (P < 0.001). However, none of these patients had an anticardiolipin IgG antibody level higher than 20 GPL, which is accepted as a clinically significant value, so this association may not be clinically important. There was no association with the microvascular complications. There was also no significant association between anti-beta2 glycoprotein I antibodies in type 2 diabetic patients and micro and macrovascular complications. Anticardiolipin and anti-beta2 glycoprotein I antibodies do not have a major role in the pathogenesis of diabetic complications in type 2 diabetic patients. Prospective studies of large populations are needed to explore this association further.
抗心磷脂抗体和抗β2糖蛋白I抗体通过多种机制与血栓形成倾向增加有关。本研究旨在评估糖尿病微血管和大血管并发症与抗心磷脂抗体和抗β2糖蛋白I抗体之间的关联。对46例2型糖尿病（T2DM）患者进行了研究。21例患者患有冠状动脉疾病这一大血管并发症。25名年龄和性别匹配的健康受试者组成对照组。对患者组和对照组均研究了抗心磷脂IgM、IgG、抗β2糖蛋白IgM和IgG抗体水平。患有缺血性心脏病的糖尿病患者的抗心磷脂IgG抗体滴度显著高于无缺血性心脏病的患者（P < 0.001）。然而，这些患者中没有一人的抗心磷脂IgG抗体水平高于20 GPL（这一水平被认为具有临床意义），因此这种关联可能在临床上并不重要。与微血管并发症无关联。2型糖尿病患者的抗β2糖蛋白I抗体与微血管和大血管并发症之间也无显著关联。抗心磷脂抗体和抗β2糖蛋白I抗体在2型糖尿病患者糖尿病并发症的发病机制中不起主要作用。需要对大量人群进行前瞻性研究以进一步探讨这种关联。
