Frosch Dominick L, Mello Paul, Lerman Caryn
Robert Wood Johnson Health and Society Scholars Program, Philadelphia, Pennsylvania, USA.
Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1485-9. doi: 10.1158/1055-9965.EPI-04-0913.
There is considerable hope that genetic susceptibility testing will motivate behavior that can prevent or reduce the risk of complex conditions such as obesity. This study examined potential behavioral consequences of such testing.
Participants (n = 249) were randomly assigned to review one of four vignettes that asked them to imagine that they had been tested for their risk of becoming overweight or obese. The experimental factors were test type (genetic versus hormone test) and risk level (increased versus average risk for obesity). Study measures included behavioral intentions and perceived behavioral control related to eating a healthy diet, as well as weight locus of control.
Participants assigned to the increased risk conditions indicated greater intentions to eat a healthy diet compared with participants assigned to the average risk conditions (P < 0.02). There were significant interaction effects of risk x perceived behavioral control (P < 0.02) and risk x weight locus of control (P < 0.003) on dietary intentions. Individuals with low perceived behavioral control or an external weight locus of control who were told to imagine they were at average risk expressed significantly lower intentions to eat a healthy diet. A three-way interaction of body mass index, family history of overweight/obesity, and assigned risk level found the greatest effects of risk feedback among those who either had a family history or a higher body mass index (P < 0.007).
This study provides preliminary evidence that testing for susceptibility to obesity may motivate healthier behavior. However, some individuals may be susceptible to a false reassurance effect after receiving test results indicating a lack of increased risk.
人们寄厚望于基因易感性检测能促使人们采取行为来预防或降低肥胖等复杂疾病的风险。本研究探讨了此类检测可能产生的行为后果。
参与者(n = 249)被随机分配去阅读四个小故事中的一个,这些小故事要求他们想象自己已接受了超重或肥胖风险检测。实验因素为检测类型(基因检测与激素检测)和风险水平(肥胖风险增加与平均风险)。研究指标包括与健康饮食相关的行为意图和感知行为控制,以及体重控制点。
与被分配到平均风险组的参与者相比,被分配到风险增加组的参与者表示有更强的健康饮食意图(P < 0.02)。风险×感知行为控制(P < 0.02)和风险×体重控制点(P < 0.003)对饮食意图有显著的交互作用。被告知想象自己处于平均风险的、感知行为控制低或体重控制点为外部的个体,表达出的健康饮食意图显著更低。体重指数、超重/肥胖家族史和分配的风险水平的三向交互作用发现,在有家族史或体重指数较高的人群中,风险反馈的影响最大(P < 0.007)。
本研究提供了初步证据,表明肥胖易感性检测可能促使人们采取更健康的行为。然而,一些个体在收到表明风险未增加的检测结果后,可能容易受到错误安心效应的影响。