Bendall L
Westmead Institute for Cancer Research, Westmead Millennium Institute, University of Sydney, Westmead, NSW 2145, Australia.
Histol Histopathol. 2005 Jul;20(3):907-26. doi: 10.14670/HH-20.907.
Chemokines are a family of structurally related low molecular weight (8-10 kDa) proteins that are important for the organization of tissues during development and regulate cell motility and localization both during development and in the adult. In the adult, this function is predominantly related to the trafficking of leukocytes, although more recently the impact of these molecules on other cell types has become apparent. Chemokines mediate their effects by binding seven transmembrane, G-protein coupled, receptors. In addition to their primary role in regulating cell motility, they can also influence cell survival and proliferation. Antagonists for a number of chemokine receptor have been developed, raising the possibility of interfering with chemokine function as a therapeutic tool. This review focuses on the emerging roles for chemokines in normal physiology and disease.
趋化因子是一类结构相关的低分子量（8 - 10 kDa）蛋白质，在发育过程中对组织的形成很重要，并且在发育过程和成年期均调节细胞运动和定位。在成年期，此功能主要与白细胞的运输有关，尽管最近这些分子对其他细胞类型的影响也已显现。趋化因子通过结合七跨膜、G蛋白偶联受体来介导其作用。除了在调节细胞运动中的主要作用外，它们还可影响细胞存活和增殖。已经开发出多种趋化因子受体拮抗剂，增加了将干扰趋化因子功能作为治疗工具的可能性。本综述重点关注趋化因子在正常生理学和疾病中的新作用。
