Yates Catherine, Amyes Sebastian
Medical Microbiology, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK.
J Antimicrob Chemother. 2005 Aug;56(2):262-4. doi: 10.1093/jac/dki237. Epub 2005 Jul 6.
In February 2004, we reported the first recognition of the presence of an extended-spectrum beta-lactamase (ESBL) in non-typhoidal Salmonella spp. in the UK; the beta-lactamase was TEM-52. Six months later, an SHV-derived ESBL (SHV-12) was detected in a salmonella strain isolated in York and 6 months after that we have just identified CTX-M-type beta-lactamases in Scottish isolates of Salmonella enterica subsp. enterica serovar Typhimurium and Salmonella Virchow (unpublished results). A very recent retrospective study of UK isolates suggests that they may have been in the population for some years but have gone undetected. Even so, compared with reports of ESBLs in Salmonella spp. elsewhere, these results are suggestive of a delayed emergence of the ESBL phenotype in non-typhoidal Salmonella spp. in the UK. Should the British congratulate themselves on warding off the emergence of these important resistance mechanisms in Salmonella spp., or is the sudden revelation of three of the major ESBL types a cause for concern?
2004年2月，我们报道了在英国非伤寒沙门氏菌中首次发现超广谱β-内酰胺酶（ESBL）；该β-内酰胺酶为TEM-52。6个月后，在约克分离出的一株沙门氏菌中检测到一种源自SHV的ESBL（SHV-12），又过了6个月，我们刚刚在肠炎沙门氏菌亚种肠炎血清型鼠伤寒沙门氏菌和维尔肖沙门氏菌的苏格兰分离株中鉴定出CTX-M型β-内酰胺酶（未发表结果）。最近一项对英国分离株的回顾性研究表明，它们可能已在人群中存在数年但未被发现。即便如此，与其他地方沙门氏菌中ESBL的报道相比，这些结果表明在英国非伤寒沙门氏菌中超广谱β-内酰胺酶表型的出现有所延迟。英国人是该庆幸自己成功抵御了沙门氏菌中这些重要耐药机制的出现呢，还是这三种主要ESBL类型的突然发现令人担忧呢？
