Keles Bahar, Ozturk Kayhan, Arbag Hamdi, Gunel Engin, Ozer Bedri
Department of Otolaryngology, Meram Medical Faculty, Selcuk University, 42090 Meram, Konya, Turkey.
Int J Pediatr Otorhinolaryngol. 2005 Aug;69(8):1103-7. doi: 10.1016/j.ijporl.2005.02.019. Epub 2005 Apr 18.
The purpose of the study is to investigate whether there is any association between pharyngeal reflux and adenoid hyperplasia by using 24-h esophageal pH monitoring with a dual probe in children.
The study group consisted of 30 children with adenoid hyperplasia, and the control group consisted of 12 healthy children, studied prospectively. All children underwent 24-h esophageal pH monitoring with a dual probe (distal and proximal esophageal pH monitoring). The results were evaluated by the Measurement and Analysis Software of Medical Measurement System program (Version: 7.2a).
In the study group, the frequency of pharyngeal reflux was 46.7% and the gastroesophageal reflux (GER) was 64.5%, while, in the control group, they were 8.3% and 25%, respectively. There was a significant difference between study and control groups for frequencies of pharyngeal reflux and GER. Mean adenoid nasopharyngeal ratio (ANR) was 0.78+/-0.11 in children with adenoid hyperplasia. There was not a significant difference between positive pharyngeal reflux, positive GER and mean ANR (p>0.05).
Children with adenoid hyperplasia had higher frequency of pharyngeal reflux than children at the same age healthy group. These results supported that pharyngeal reflux may play an important role in the etiology of adenoid hyperplasia.
本研究旨在通过对儿童使用双探头进行24小时食管pH监测，调查咽反流与腺样体增生之间是否存在关联。
研究组由30例腺样体增生患儿组成，对照组由12例健康儿童组成，进行前瞻性研究。所有儿童均使用双探头进行24小时食管pH监测（食管远端和近端pH监测）。结果通过医学测量系统程序的测量与分析软件（版本：7.2a）进行评估。
研究组中，咽反流频率为46.7%，胃食管反流（GER）频率为64.5%，而对照组中，咽反流频率和GER频率分别为8.3%和25%。研究组与对照组在咽反流和GER频率方面存在显著差异。腺样体增生患儿的平均腺样体鼻咽比值（ANR）为0.78±0.11。咽反流阳性、GER阳性与平均ANR之间无显著差异（p>0.05）。
腺样体增生患儿的咽反流频率高于同年龄健康组儿童。这些结果支持咽反流可能在腺样体增生的病因学中起重要作用。
