Huang M T, Ho C T, Wang Z Y, Ferraro T, Finnegan-Olive T, Lou Y R, Mitchell J M, Laskin J D, Newmark H, Yang C S
Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers, State University of New Jersey, Piscataway 08855-0789.
Carcinogenesis. 1992 Jun;13(6):947-54. doi: 10.1093/carcin/13.6.947.
A green tea polyphenol fraction was evaluated for its ability to inhibit tumor initiation by polycyclic aromatic hydrocarbons and tumor promotion by a phorbol ester in the skin of CD-1 mice. Topical application of the green tea polyphenol fraction inhibited benzo[a]pyrene- and 7,12-dimethylbenz[a]-anthracene-induced tumor initiation as well as 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion. Topical application of the green tea polyphenol fraction also inhibited TPA-induced inflammation, ornithine decarboxylase activity, hyperplasia and hydrogen peroxide formation. Studies with individual polyphenolic compounds in green tea indicated that topical application of (-)-epigallocatechin gallate, (-)-epigallocatechin and (-)-epicatechin gallate inhibited TPA-induced inflammation in mouse epidermis.
对绿茶多酚组分抑制CD-1小鼠皮肤中多环芳烃引发肿瘤及佛波酯促进肿瘤的能力进行了评估。局部应用绿茶多酚组分可抑制苯并[a]芘和7,12-二甲基苯并[a]蒽诱导的肿瘤引发，以及12-O-十四烷酰佛波醇-13-乙酸酯（TPA）诱导的肿瘤促进。局部应用绿茶多酚组分还可抑制TPA诱导的炎症、鸟氨酸脱羧酶活性、增生和过氧化氢生成。对绿茶中单个多酚化合物的研究表明，局部应用（-）-表没食子儿茶素没食子酸酯、（-）-表没食子儿茶素和（-）-表儿茶素没食子酸酯可抑制小鼠表皮中TPA诱导的炎症。
