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对于体外受精所获取的人类卵母细胞,其卵泡液激素浓度、受精能力和细胞遗传学分析之间是否存在任何相关性?

Is there any correlation between follicular fluid hormone concentrations, fertilizability, and cytogenetic analysis of human oocytes recovered for in vitro fertilization?

作者信息

Rosenbusch B, Djalali M, Sterzik K

机构信息

Department of Gynecology and Obstetrics, University of Ulm, Germany.

出版信息

Fertil Steril. 1992 Jun;57(6):1358-60. doi: 10.1016/s0015-0282(16)55105-x.

DOI:10.1016/s0015-0282(16)55105-x
PMID:1601167
Abstract

Constituents of FF have been suspected to influence fertilizability and cytogenetic constitution of human oocytes. We therefore analyzed the FF concentrations of E2, P, T, and PRL for 114 oocytes recovered for IVF. Forty-six of these oocytes were fertilized and transferred to the maternal uterus. Among the unfertilized gametes, 27 were not analyzable, 30 were normal haploid, and 11 were classified as abnormal. There was no significant difference between fertilized and unfertilized oocytes for FF concentrations of E2, P, T, and PRL and for the E2:P ratios. Similarly, we detected no significant difference between normal and abnormal oocytes for these parameters.

摘要

卵泡液的成分被怀疑会影响人类卵母细胞的受精能力和细胞遗传学构成。因此,我们分析了114个为体外受精而回收的卵母细胞的卵泡液中雌二醇(E2)、孕酮(P)、睾酮(T)和催乳素(PRL)的浓度。其中46个卵母细胞受精并移植到母体子宫。在未受精的配子中,27个无法分析,30个为正常单倍体,11个被归类为异常。受精和未受精卵母细胞在卵泡液中E2、P、T和PRL的浓度以及E2:P比值方面没有显著差异。同样,我们在这些参数上未检测到正常和异常卵母细胞之间存在显著差异。

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