Departments of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison WI, USA.
Department of Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Semin Immunol. 2023 Jan;65:101673. doi: 10.1016/j.smim.2022.101673. Epub 2022 Nov 29.
Fungi are ubiquitous commensals, seasoned predators, and important agents of emerging infectious diseases [1]. The immune system assumes the essential responsibility for responding intelligently to the presence of known and novel fungi to maintain host health. In this Review, we describe the immune responses to pathogenic fungi and the varied array of fungal agents confronting the vertebrate host within the broader context of fungal and animal evolution. We provide an overview of the mechanistic details of innate and adaptive antifungal immune responses, as well as ways in which these basic mechanisms support the development of vaccines and immunotherapies.
真菌是无处不在的共生生物、经验丰富的捕食者，也是新发传染病的重要病原体[1]。免疫系统承担着对已知和新型真菌存在做出智能响应的重要责任，以维持宿主健康。在这篇综述中，我们描述了针对病原真菌的免疫反应，以及在真菌和动物进化的更广泛背景下，脊椎动物宿主所面临的各种真菌病原体。我们概述了先天和适应性抗真菌免疫反应的机制细节，以及这些基本机制如何支持疫苗和免疫疗法的发展。
