Thiele Jens J, Hsieh Sherry N, Ekanayake-Mudiyanselage Swarna
Department of Dermatology, Northwestern University Medical School, Chicago, IL 60611, USA.
Dermatol Surg. 2005 Jul;31(7 Pt 2):805-13; discussion 813. doi: 10.1111/j.1524-4725.2005.31724.
The lipophilic antioxidant vitamin E has been used for more than 50 years in clinical and experimental dermatology. However, although a large number of case reports were published, there is still a lack of controlled clinical studies providing a rationale for clinical indications and dosage. In contrast, advances in basic research on the physiology, mechanism of action, penetration, bioconversion, and photoprotection of vitamin E in human skin have led to the development of numerous new formulations for use in cosmetics and skin care products.
This article reviews the basic mechanisms and possible cosmetical and clinical implications of the recent advances in cutaneous vitamin E research. Experimental evidence suggests that topical and oral vitamin E has anticarcinogenic, photoprotective, and skin barrier-stabilizing properties.
Although its current use is largely limited to cosmetics, controlled clinical studies for indications such as atopic dermatitis or prevention of photocarcinogenesis are needed to evaluate the clinical benefit of vitamin E.
亲脂性抗氧化剂维生素E已在临床和实验皮肤病学中应用了50多年。然而，尽管发表了大量病例报告，但仍缺乏对照临床研究来为临床适应症和剂量提供理论依据。相比之下，关于维生素E在人体皮肤中的生理学、作用机制、渗透、生物转化和光保护的基础研究进展，已促使众多用于化妆品和护肤品的新配方得以开发。
本文综述了皮肤维生素E研究最新进展的基本机制以及可能的美容和临床意义。实验证据表明，局部和口服维生素E具有抗癌、光保护和稳定皮肤屏障的特性。
尽管其目前主要限于化妆品应用，但需要针对特应性皮炎或预防光致癌等适应症进行对照临床研究，以评估维生素E的临床益处。
