Weizman A, Mandel A, Barber Y, Weitz R, Cohen A, Mester R, Rehavi M
Geha Psychiatric Hospital, Petah-Tiqva, Israel.
Biol Psychiatry. 1992 Apr 1;31(7):705-11. doi: 10.1016/0006-3223(92)90280-d.
[3H]Imipramine binding to blood platelets was assessed in eight untreated Tourette syndrome (TS) children, nine drug-free TS children with obsessive-compulsive disorder (OCD), and nine age-matched and gender-matched control subjects. The density of [3H]imipramine binding sites in TS + OCD patients was significantly lower compared with TS-OCD patients (28%) as well as when compared with controls (31%). This alteration was not accompanied by differences in the affinity of the binding site to the ligand. The decreased density of the platelet serotonin "transporter" might implicate the involvement of the serotonergic system in the pathophysiology of OCD in TS patients, but not in TS per se.
在8名未经治疗的抽动秽语综合征（TS）儿童、9名无药物治疗的患有强迫症（OCD）的TS儿童以及9名年龄和性别匹配的对照受试者中评估了[3H]丙咪嗪与血小板的结合情况。与无OCD的TS患者相比，TS + OCD患者中[3H]丙咪嗪结合位点的密度显著降低（28%），与对照组相比也降低（31%）。这种改变并未伴随着结合位点对配体亲和力的差异。血小板5-羟色胺“转运体”密度的降低可能意味着5-羟色胺能系统参与了TS患者OCD的病理生理学过程，但不参与TS本身的病理生理学过程。
