强迫症患者的血小板丙咪嗪结合及血清素摄取情况

Platelet imipramine binding and serotonin uptake in obsessive-compulsive patients.

作者信息

Vitiello B, Shimon H, Behar D, Stoff D, Bridger W H, Friedman E

机构信息

Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia.

出版信息

Acta Psychiatr Scand. 1991 Jul;84(1):29-32. doi: 10.1111/j.1600-0447.1991.tb01417.x.

DOI:10.1111/j.1600-0447.1991.tb01417.x

Abstract

Platelet imipramine binding was measured in 16 drug-free nondepressed patients (aged 20-61 years, mean +/- SD 35 +/- 8) suffering from obsessive-compulsive disorder (OCD) and in 16 sex-, race- and age-matched healthy controls. Imipramine binding capacity and affinity were not different in the 2 groups. Platelet serotonin (5-HT) uptake capacity, Vmax, was also measured in 15 of these patients and their matched controls. Vmax was significantly higher in the patients (309 +/- 149 pmol/10(9) cells/min) than in the controls (181 +/- 110). An increase in platelet 5-HT uptake supports the involvement of 5-HT in OCD and may suggest that a hyperactive serotonergic system is present in this disorder.

摘要

对16名患有强迫症（OCD）的未服用药物的非抑郁症患者（年龄20 - 61岁，平均±标准差35±8）和16名性别、种族及年龄匹配的健康对照者测量了血小板丙咪嗪结合情况。两组的丙咪嗪结合能力和亲和力并无差异。还对其中15名患者及其匹配的对照者测量了血小板5 - 羟色胺（5 - HT）摄取能力Vmax。患者的Vmax（309±149 pmol/10⁹细胞/分钟）显著高于对照者（181±110）。血小板5 - HT摄取增加支持5 - HT参与强迫症，且可能提示该疾病存在5 - 羟色胺能系统亢进。

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