Roehrs T, Merlotti L, Zorick F, Roth T
Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, MI 48202.
Psychopharmacology (Berl). 1992;107(4):480-4. doi: 10.1007/BF02245259.
Twenty-one (three groups of seven), men and women, 25-50 years of age were studied to determine whether or not rebound insomnia would increase the likelihood of self administering a benzodiazepine (triazolam 0.25 mg) hypnotic. The groups compared were patients with insomnia and disturbed sleep, insomnia and normal sleep, and healthy normals. Rebound insomnia, by both subjective and polysomnographic assessment, was induced. The experience of rebound insomnia did not increase the likelihood of self administering a benzodiazepine hypnotic in any of the groups. There were clear group differences in pill self administration with normals rarely and insomnia patients frequently, but not differentially (placebo versus active drug) self administering pills.
研究了21名年龄在25至50岁之间的男女（分为三组，每组7人），以确定反弹性失眠是否会增加自行服用苯二氮䓬类（三唑仑0.25毫克）催眠药的可能性。所比较的组包括失眠且睡眠紊乱的患者、失眠且睡眠正常的患者以及健康正常人。通过主观和多导睡眠图评估诱导出反弹性失眠。反弹性失眠的经历在任何一组中都未增加自行服用苯二氮䓬类催眠药的可能性。在自行服药方面存在明显的组间差异，正常人很少自行服药，失眠患者则经常自行服药，但在（安慰剂与活性药物）自行服药方面没有差异。
