Morrens M, Hulstijn W, Van Hecke J, Peuskens J, Sabbe B G C
Collaborative Antwerp Psychiatric Research Institute, Campus Drie Eiken, Universiteitsplein 1, B-2610 Antwerp, Wilrijk, Belgium.
J Psychiatr Res. 2006 Apr;40(3):200-6. doi: 10.1016/j.jpsychires.2005.04.014. Epub 2005 Jul 21.
A vast amount of studies demonstrates the presence of psychomotor slowing in schizophrenia. The objective of the present study was to investigate whether this overall psychomotor slowing can be divided into distinct processes that differentially affect cognitive functioning in schizophrenia.
The pen-tip movements of 30 schizophrenic inpatients and 30 matched controls were digitally recorded during performance of the Symbol Digit Substitution Test (SDST) and analysed to differentiate matching time and writing time, representing the cognitive and sensorimotor component of slowing, respectively. In addition, the results were compared to each other and to the scores of traditional neuropsychological tests that assess domains such as memory and attention.
Both matching time and writing time were longer in the schizophrenic patients relative to the controls but did not correlate. Only matching time correlated significantly with the conventional neuropsychological test results.
Although schizophrenic patients display both sensorimotor and cognitive slowing, the two processes are unrelated. Furthermore, only the cognitive component was associated with most of the cognitive deficits as measured by traditional neuropsychological tests.
大量研究表明精神分裂症患者存在精神运动迟缓。本研究的目的是调查这种整体的精神运动迟缓是否可分为不同的过程，这些过程对精神分裂症患者的认知功能有不同影响。
在进行符号数字替换测验（SDST）期间，对30名精神分裂症住院患者和30名匹配的对照组的笔尖运动进行数字记录，并进行分析以区分匹配时间和书写时间，分别代表迟缓的认知和感觉运动成分。此外，将结果相互比较，并与评估记忆和注意力等领域的传统神经心理学测试得分进行比较。
与对照组相比，精神分裂症患者的匹配时间和书写时间均更长，但两者不相关。只有匹配时间与传统神经心理学测试结果显著相关。
虽然精神分裂症患者表现出感觉运动和认知迟缓，但这两个过程不相关。此外，通过传统神经心理学测试测量，只有认知成分与大多数认知缺陷相关。
