Kwon Dur Han, Kwon Hyuk Yun, Kim Hyun Jung, Chang Eun Joo, Kim Man Bae, Yoon Seung Kew, Song Eun Young, Yoon Do Young, Lee Young Hee, Choi In Seong, Choi Yong Kyung
Cell Biology Laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejon 305-333, Republic of Korea.
Phytother Res. 2005 Apr;19(4):355-8. doi: 10.1002/ptr.1689.
Inhibition of HBsAg release against hepatitis B virus (HBV) was investigated in an aqueous extract prepared from the aerial parts (stems and leaves) of Agrimonia eupatoria. The inhibitory effect on HBsAg secretion was footed using aqueous extracts of Agrimonia eupatoria at four different temperatures (37 degrees C 45 degrees C, 55 degrees C and 60 degrees C), and the extract prepared at 60 degrees C was found to have the greatest effect. The inhibitory activity of Agrimonia eupatoria extracts on HBsAg secretion varied over the growing season and was the highest at mid-July. This inhibitory activity was also shown with the aqueous extracts of two other species of the genus Agrimonia: A. pilosa and A. coreana pilosella. These results suggest that some plants of the genus Agrimonia contain potential antiviral activity against HBV.
对从 Agrimonia eupatoria 的地上部分（茎和叶）制备的水提取物中针对乙型肝炎病毒（HBV）的 HBsAg 释放抑制作用进行了研究。使用 Agrimonia eupatoria 的水提取物在四个不同温度（37℃、45℃、55℃和 60℃）下考察对 HBsAg 分泌的抑制作用，发现 60℃制备的提取物具有最大效果。Agrimonia eupatoria 提取物对 HBsAg 分泌的抑制活性在生长季节有所变化，在 7 月中旬最高。Agrimonia 属的另外两个物种：A. pilosa 和 A. coreana pilosella 的水提取物也显示出这种抑制活性。这些结果表明，Agrimonia 属的一些植物含有针对 HBV 的潜在抗病毒活性。
