聚醚对人类免疫缺陷病毒复制的抑制作用。
Inhibitory effects of polyethers on human immunodeficiency virus replication.
作者信息
Nakamura M, Kunimoto S, Takahashi Y, Naganawa H, Sakaue M, Inoue S, Ohno T, Takeuchi T
机构信息
Department of Microbiology, Jikei University School of Medicine, Tokyo, Japan.
出版信息
Antimicrob Agents Chemother. 1992 Feb;36(2):492-4. doi: 10.1128/AAC.36.2.492.
Abstract
We examined the inhibitory activities of 10 polyether antibiotics on human immunodeficiency virus (HIV) type 1. These compounds caused concentration-dependent inhibition of HIV replication in primary infected cultures of human T-lymphoblastoid H9 cells. The ratio of 50% effective concentrations for cellular cytotoxicity (MTT assay) to antiviral activity (reverse transcriptase assay) was over 5. Anti-HIV activity was also observed in cultures of monocytic lineage U937 cells chronically infected with HIV.
摘要
我们检测了10种聚醚抗生素对1型人类免疫缺陷病毒（HIV）的抑制活性。这些化合物在人T淋巴母细胞样H9细胞的原代感染培养物中引起了HIV复制的浓度依赖性抑制。细胞毒性（MTT法）与抗病毒活性（逆转录酶法）的50%有效浓度之比超过5。在长期感染HIV的单核细胞系U937细胞培养物中也观察到了抗HIV活性。
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