Trenkwalder C, Straube A, Paulus W, Krafczyk S, Schielke E, Einhäupl K M
Department of Neurology, University of Munich, Klinikum Grosshadern, Federal Republic of Germany.
Eur Arch Psychiatry Clin Neurosci. 1992;241(5):267-72. doi: 10.1007/BF02195975.
We have recorded postural performance in 50 HIV-infected patients in different stages of the disease (Walter Reed (WR) stages I-VI) by means of a force measuring platform. The results were compared with 50 age-matched controls. A significant instability was particularly evident when standing on an unstable foot support. In patients standing with "eyes closed", postural sway was significantly higher in every patient group (WR I-II: P less than 0.02, WR III-V: P less than 0.001, WR VI: P less than 0.001). Patients in stage WR I-II showed no relevant neurological abnormalities. In agreement with other neurophysiological data in the literature we suggest that postural imbalance could be an early sign of central nervous system penetration of HIV. No correlation with electromyographic or cerebrospinal fluid findings could be found.
我们通过测力平台记录了50名处于疾病不同阶段（沃尔特·里德（WR）I - VI期）的HIV感染患者的姿势表现。将结果与50名年龄匹配的对照组进行了比较。当站在不稳定的足部支撑上时，明显的不稳定性尤为明显。在“闭眼”站立的患者中，每个患者组的姿势摆动都显著更高（WR I - II期：P < 0.02，WR III - V期：P < 0.001，WR VI期：P < 0.001）。WR I - II期的患者没有相关的神经学异常。与文献中的其他神经生理学数据一致，我们认为姿势失衡可能是HIV侵犯中枢神经系统的早期迹象。未发现与肌电图或脑脊液检查结果有相关性。
