Ogura S, Abe S, Sukoh N, Kunikane H, Nakajima I, Inoue K, Kawakami Y
First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan.
Cancer. 1992 Jul 1;70(1):63-8. doi: 10.1002/1097-0142(19920701)70:1<63::aid-cncr2820700111>3.0.co;2-v.
The value of nucleolar organizer regions (NOR) visualized by silver staining (AgNOR) for the histologic differentiation, pathologic staging, and estimation of growth rate was assessed by the investigation of paraffin sections from 58 lung adenocarcinomas. AgNOR consist of NOR-associated proteins, and the number of AgNOR might be related to proliferative activity.
In lung adenocarcinoma, the growth rate can be measured by means of chest radiographs. Using this technique, the authors studied the correlation between the mean number of AgNOR and growth rate.
The mean number of AgNOR ranged from 1.8 to 6.3 (mean +/- standard deviation, 4.0 +/- 0.8). Neither the degree of histologic differentiation nor the pathologic staging was related to the AgNOR count. The tumor growth rate was estimated on the basis of the doubling time in the chest radiographs of 13 patients. The doubling time ranged from 80 to 760 days. There was a high inverse correlation between the AgNOR count and the doubling time (r = -0.910; P less than 0.001).
Thus, it appears to be possible to use the mean number of AgNOR as an index of proliferative activity.
通过对58例肺腺癌石蜡切片的研究，评估了银染法（AgNOR）显示的核仁组成区（NOR）在组织学分化、病理分期及生长速率评估方面的价值。AgNOR由与NOR相关的蛋白质组成，AgNOR的数量可能与增殖活性有关。
在肺腺癌中，可通过胸部X线片测量生长速率。作者采用该技术研究了AgNOR平均数与生长速率之间的相关性。
AgNOR平均数在1.8至6.3之间（均值±标准差，4.0±0.8）。组织学分化程度及病理分期均与AgNOR计数无关。根据13例患者胸部X线片的倍增时间估算肿瘤生长速率。倍增时间在80至760天之间。AgNOR计数与倍增时间呈高度负相关（r = -0.910；P<0.001）。
因此，似乎可以将AgNOR平均数用作增殖活性的指标。
