Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan.
J Nat Med. 2010 Oct;64(4):496-9. doi: 10.1007/s11418-010-0435-4. Epub 2010 Jun 23.
A novel alpha-tetralonyl derivative, juglanone, was isolated from the fresh unripe fruits of Juglans mandshurica. Its structure was determined by spectroscopic analyses and from chemical evidence. Juglanone exhibited significant antioxidant activity in assays for 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and superoxide dismutase-like activity with IC(50) values of 10.1 and 9.0 microM, respectively. It also showed moderate cytotoxic activity against HL-60 human myeloid leukemia with an IC(50) value of 19.7 microM.
从鲜未成熟的核桃楸果实中分离得到一种新型的α-四氢萘酮衍生物，胡桃酮。其结构通过光谱分析和化学证据确定。胡桃酮在 1,1-二苯基-2-苦基肼自由基清除活性和超氧化物歧化酶样活性测定中表现出显著的抗氧化活性，IC50 值分别为 10.1 和 9.0 μM。它对 HL-60 人髓样白血病也表现出中等的细胞毒性活性，IC50 值为 19.7 μM。
