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Bacteremia caused by multiply resistant corynebacterium urealyticum: six case reports and review.多重耐药解脲棒状杆菌引起的菌血症：6例报告及文献复习
Eur J Clin Microbiol Infect Dis. 2001 Jul;20(7):514-7. doi: 10.1007/pl00011297.
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Corynebacterium jeikeium bacteremia in bone marrow transplant patients with Hickman catheters.携带希克曼导管的骨髓移植患者发生杰氏棒状杆菌菌血症。
Bone Marrow Transplant. 2001 Feb;27(4):445-9. doi: 10.1038/sj.bmt.1702808.
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Proposal of Sphingomonadaceae fam. nov., consisting of Sphingomonas Yabuuchi et al. 1990, Erythrobacter Shiba and Shimidu 1982, Erythromicrobium Yurkov et al. 1994, Porphyrobacter Fuerst et al. 1993, Zymomonas Kluyver and van Niel 1936, and Sandaracinobacter Yurkov et al. 1997, with the type genus Sphingomonas Yabuuchi et al. 1990.鞘脂单胞菌科新属的提议，该科包含1990年的矢布uchi等人发现的鞘脂单胞菌属、1982年的Shiba和Shimidu发现的红杆菌属、1994年的Yurkov等人发现的红微菌属、1993年的Fuerst等人发现的卟啉杆菌属、1936年的Kluyver和van Niel发现的发酵单胞菌属以及1997年的Yurkov等人发现的桑德拉辛杆菌属，模式属为1990年矢布uchi等人发现的鞘脂单胞菌属。
Microbiol Immunol. 2000;44(7):563-75. doi: 10.1111/j.1348-0421.2000.tb02535.x.
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Phenotypic and phylogenetic characterization of a new Corynebacterium species from dogs: description of Corynebacterium auriscanis sp. nov.犬源新棒状杆菌物种的表型和系统发育特征：耳道棒状杆菌新种的描述
J Clin Microbiol. 1999 Nov;37(11):3443-7. doi: 10.1128/JCM.37.11.3443-3447.1999.
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Clinical microbiology of coryneform bacteria.棒状杆菌的临床微生物学
Clin Microbiol Rev. 1997 Jan;10(1):125-59. doi: 10.1128/CMR.10.1.125.
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TreeView: an application to display phylogenetic trees on personal computers.树形视图：一款在个人电脑上显示系统发育树的应用程序。
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16S ribosomal DNA sequences of anaerobic cocci and proposal of Ruminococcus hansenii comb. nov. and Ruminococcus productus comb. nov.厌氧球菌的16S核糖体DNA序列及汉森瘤胃球菌（新组合）和产瘤胃球菌（新组合）的提议
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[A case of Corynebacterium jeikeium septicemia].[杰氏棒状杆菌败血症一例]
Kansenshogaku Zasshi. 1994 Dec;68(12):1527-32. doi: 10.11150/kansenshogakuzasshi1970.68.1527.
10
Antimicrobial susceptibilities of Corynebacterium species and other non-spore-forming gram-positive bacilli to 18 antimicrobial agents.棒状杆菌属菌种及其他非芽孢形成革兰氏阳性杆菌对18种抗菌药物的药敏情况
Antimicrob Agents Chemother. 1995 Jan;39(1):208-14. doi: 10.1128/AAC.39.1.208.

抗药棒状杆菌新种，一种从人类感染中分离出的新型多重耐药棒状细菌。

Corynebacterium resistens sp. nov., a new multidrug-resistant coryneform bacterium isolated from human infections.

作者信息

Otsuka Yoshihito, Kawamura Yoshiaki, Koyama Takashi, Iihara Hirotoshi, Ohkusu Kiyofumi, Ezaki Takayuki

机构信息

Department of Laboratory Medicine, Social Insurance Central General Hospital, Tokyo, Japan.

出版信息

J Clin Microbiol. 2005 Aug;43(8):3713-7. doi: 10.1128/JCM.43.8.3713-3717.2005.

DOI:10.1128/JCM.43.8.3713-3717.2005
PMID:16081900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1233995/
Abstract

Five strains of an unknown, multidrug-resistant coryneform, gram-positive rod were isolated from blood, bronchial aspirate, and abscess specimens. Four of the five strains isolated were highly resistant to antimicrobial agents, including beta-lactams, aminoglycosides, macrolides, quinolones, and tetracyclines, except for glycopeptides. In immunocompromised patients, bacteremia associated with this organism was rapidly fatal. This coryneform bacterium was nonmotile, lipophilic, and nonsaccharolytic. Lack of pyrazinamidase activity differentiated this organism from other lipophilic corynebacteria. Chemotaxonomic studies indicated that this multidrug-resistant coryneform bacterium belongs to the genus Corynebacterium. Comparative 16S rRNA gene sequencing and DNA-DNA hybridization analyses revealed that the five isolates were genetically identical and that they represent a new subline within the genus Corynebacterium, for which we propose the designation Corynebacterium resistens sp. nov. The type strain of Corynebacterium resistens is GTC 2026T (SICGH 158T, JCM 12819T, CCUG 50093T).

摘要

从血液、支气管吸出物和脓肿标本中分离出五株未知的、耐多药的棒状革兰氏阳性杆菌。分离出的五株菌株中有四株对多种抗菌药物高度耐药，包括β-内酰胺类、氨基糖苷类、大环内酯类、喹诺酮类和四环素类，但对糖肽类药物敏感。在免疫功能低下的患者中，与这种微生物相关的菌血症进展迅速，可导致死亡。这种棒状细菌无运动性、嗜脂性且不分解糖类。缺乏吡嗪酰胺酶活性可将该微生物与其他嗜脂性棒状杆菌区分开来。化学分类学研究表明，这种耐多药的棒状细菌属于棒状杆菌属。比较16S rRNA基因测序和DNA-DNA杂交分析显示，这五株分离株在基因上是相同的，它们代表了棒状杆菌属内的一个新亚系，我们将其命名为抗药棒状杆菌（Corynebacterium resistens sp. nov.）。抗药棒状杆菌的模式菌株是GTC 2026T（SICGH 158T、JCM 12819T、CCUG 50093T）。