经超声检查证实的北印度 2 型糖尿病女性多囊卵巢的患病率。
Prevalence of ultrasonography proved polycystic ovaries in North Indian women with type 2 diabetes mellitus.
作者信息
Zargar Abdul H, Gupta Vipin K, Wani Arshad I, Masoodi Shariq R, Bashir Mir I, Laway Bashir A, Ganie Mohammad A, Salahuddin Mohammad
机构信息
Department of Endocrinology, Sheri-Kashmir Institute of Medical Sciences Srinagar, J&K, India.
出版信息
Reprod Biol Endocrinol. 2005 Aug 11;3:35. doi: 10.1186/1477-7827-3-35.
BACKGROUND
Polycystic ovaries (PCO) and their clinical expression (the polycystic ovary syndrome [PCOS]) as well as type 2 diabetes mellitus (T2DM) are common medical conditions linked through insulin resistance. We studied the prevalence of PCO and PCOS in women with diet and/or oral hypoglycemic treated T2DM and non-diabetic control women.
DESIGN
Prospective study.
METHODS
One hundred and five reproductive age group women with diet and /or oral hypoglycemic treated T2DM were the subjects of the study. Sixty age-matched non-diabetic women served as controls. Transabdominal ultrasonographic assessment of the ovaries was used to diagnose PCO. Clinical, biochemical and hormonal parameters were also noted.
RESULTS
Ultrasonographic prevalence of PCO was higher in women with diabetes than in non-diabetic subjects (61.0% vs. 36.7%, P < 0.003) whereas that of PCOS was 37.1% in diabetic subjects and 25% in non-diabetic controls (P > 0.1). Diabetic women with PCO had diabetes of significantly longer duration than those without PCO (4.19+/-2.0 versus 2.9+/-1.6 yrs; p < 0.05). Among both diabetic and non-diabetic women, those with PCO had significantly higher plasma LH, LH/FSH ratio, total testosterone and androstenedione levels.
CONCLUSION
This study demonstrates a higher prevalence of PCO in women with T2DM as compared to non-diabetic subjects.
背景
多囊卵巢（PCO）及其临床表现（多囊卵巢综合征 [PCOS]）以及2型糖尿病（T2DM）是通过胰岛素抵抗相关联的常见病症。我们研究了饮食和/或口服降糖药治疗的T2DM女性以及非糖尿病对照女性中PCO和PCOS的患病率。
设计
前瞻性研究。
方法
105名接受饮食和/或口服降糖药治疗的育龄期T2DM女性作为研究对象。60名年龄匹配的非糖尿病女性作为对照。通过经腹超声检查卵巢来诊断PCO。还记录了临床、生化和激素参数。
结果
糖尿病女性中PCO的超声患病率高于非糖尿病受试者（61.0% 对36.7%，P < 0.003），而PCOS在糖尿病受试者中的患病率为37.1%，在非糖尿病对照中为25%（P > 0.1）。患有PCO的糖尿病女性患糖尿病的病程明显长于未患PCO的女性（4.19±2.0对2.9±1.6年；p < 0.05）。在糖尿病和非糖尿病女性中，患有PCO的女性血浆促黄体生成素（LH）、LH/FSH比值、总睾酮和雄烯二酮水平均显著更高。
结论
本研究表明，与非糖尿病受试者相比T2DM女性中PCO的患病率更高。
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