Sukantarat K T, Burgess P W, Williamson R C N, Brett S J
Department of Surgery, Hammersmith Hospital, Ducane Road, London W12 0HS, UK.
Anaesthesia. 2005 Sep;60(9):847-53. doi: 10.1111/j.1365-2044.2005.04148.x.
A prospective study using neuropsychological testing explored cognitive performance, and specifically executive function, in survivors of critical illness during the first year of recovery. Fifty-one patients who had survived 3 days or more in the intensive care unit were studied approximately 3 months after discharge; 45 of them were studied again 6 months later. General health was assessed using the Short-Form 36. Cognitive and executive functions were measured using Raven's Progressive Matrices, the Hayling Sentence completion test and the Six-Element Test. Three months after discharge from intensive care, all eight domains of Short-Form 36 were impaired among survivors; by 9 months, four of the eight domains showed significant improvement. At 3 months, 35% of patients scored at or below a level equivalent to the lowest performing 5% of a normal population (i.e. the fifth percentile) on two or more tests of cognitive function; by 9 months only 4% of patients were impaired to this extent. Although cognitive performance improved with time, it remained below normal.
一项采用神经心理学测试的前瞻性研究，探讨了危重症幸存者在康复第一年的认知表现，特别是执行功能。对51名在重症监护病房存活3天或更长时间的患者，在出院后约3个月进行了研究；其中45人在6个月后再次接受研究。使用简短健康调查问卷（Short-Form 36）评估总体健康状况。使用瑞文渐进性矩阵测验、海林句子完成测试和六元素测试来测量认知和执行功能。在从重症监护病房出院3个月后，幸存者的简短健康调查问卷的所有八个领域均受损；到9个月时，八个领域中的四个显示出显著改善。在3个月时，35%的患者在两项或更多认知功能测试中的得分处于或低于相当于正常人群中表现最差的5%（即第五百分位数）的水平；到9个月时，只有4%的患者受损程度如此。尽管认知表现随时间有所改善，但仍低于正常水平。
