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用于间歇性导尿的亲水涂层导管可减少尿道微创伤:一项对三种不同类型导管进行的前瞻性、随机、参与者盲法交叉研究。

Hydrophilic-coated catheters for intermittent catheterisation reduce urethral micro trauma: a prospective, randomised, participant-blinded, crossover study of three different types of catheters.

作者信息

Stensballe J, Looms D, Nielsen P N, Tvede M

机构信息

Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Denmark.

出版信息

Eur Urol. 2005 Dec;48(6):978-83. doi: 10.1016/j.eururo.2005.07.009. Epub 2005 Aug 2.

Abstract

OBJECTIVE

To compare two hydrophilic-coated (SpeediCath and LoFric and one uncoated gel-lubricated catheter (InCare Advance Plus) concerning withdrawal friction force and urethral micro trauma.

METHODS

49 healthy male volunteers participated in this prospective, randomised, blinded, crossover study of three different bladder catheters. The withdrawal friction force was measured, and urine analysis of blood, nitrite and leucocytes, microbiological analysis of urine cultures and subjective evaluation of the catheters were performed.

RESULTS

40 participants completed the study and were included in the analysis. SpeediCath exerted a significantly lower mean withdrawal friction force and work than the gel-lubricated uncoated catheter, whereas LoFric exerted a significantly higher mean friction force than both of the other catheters. The hydrophilic catheters caused less microscopic haematuria and less pain than the gel-lubricated uncoated catheter. Furthermore, 93% of the participants preferred the hydrophilic catheters.

CONCLUSION

Hydrophilic-coated catheters perform better than uncoated catheters with regard to haematuria and preference. SpeediCath, but not LoFric, exerts less withdrawal friction force than InCare Advance Plus.

摘要

目的

比较两种亲水涂层导尿管(SpeediCath和LoFric)和一种未涂层凝胶润滑导尿管(InCare Advance Plus)在拔出摩擦力和尿道微创伤方面的差异。

方法

49名健康男性志愿者参与了这项关于三种不同膀胱导尿管的前瞻性、随机、盲法、交叉研究。测量了拔出摩擦力,并进行了尿液中血液、亚硝酸盐和白细胞的分析、尿培养的微生物分析以及对导尿管的主观评估。

结果

40名参与者完成了研究并纳入分析。SpeediCath的平均拔出摩擦力和功显著低于未涂层凝胶润滑导尿管,而LoFric的平均摩擦力显著高于其他两种导尿管。亲水涂层导尿管引起的镜下血尿和疼痛比未涂层凝胶润滑导尿管少。此外,93%的参与者更喜欢亲水涂层导尿管。

结论

亲水涂层导尿管在血尿和患者偏好方面比未涂层导尿管表现更好。SpeediCath的拔出摩擦力比InCare Advance Plus小,而LoFric则不然。

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