JACC研究中胃癌的死亡率和发病率

Mortality and incidence rates of stomach cancer in the JACC Study.

作者信息

Truong Minh Pham, Fujino Yoshihisa, Yoshimura Takesumi, Tokui Noritaka, Mizoue Tetsuya, Yatsuya Hiroshi, Toyoshima Hideaki, Sakata Kiyomi, Kikuchi Shogo, Hoshiyama Yoshihiro, Kubo Tatsuhiko, Tamakoshi Akiko

机构信息

Department of Clinical Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan.

出版信息

J Epidemiol. 2005 Jun;15 Suppl 2(Suppl II):S89-97. doi: 10.2188/jea.15.s89.

DOI:10.2188/jea.15.s89

PMID:16127239

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8639033/

Abstract

BACKGROUND

The objective of this study was to examine the mortality and incidence of stomach cancer in the Japan Collaborative Cohort Study (JACC Study), and compare them with those of the general population of Japan.

METHODS

The cohort study involved 127,477 people living in 45 municipalities in Japan. The deaths due to stomach cancer were ascertained by death certificates. The age-adjusted mortality rate per 100,000 was calculated based on 110,792 subjects aged between 40 and 79 years at the baseline in all study areas. The incident cases were defined as the subjects in whom stomach cancer had developed, or subjects who died of stomach cancer during the observed period of survey for cancer incidence. The age-adjusted incidence rate per 100,000 was ascertained and calculated in 64,820 people aged 40-79 years at the baseline living in 24 study municipalities with cancer registries. Then, the mortality rate was compared with the mortality data published in vital statistics of Japan of 1995, and the incidence rate compared with the incidence data published in The Research Group for Populationbased Cancer Registration in Japan of 1992.

RESULTS

During more than 10 years of follow-up, there were 582 male deaths and 287 female deaths due to stomach cancer. The age-adjusted mortality rate was 93.4/100,000 person-year (95% confidence interval [CI]: 84.6-102.2) in males and 31.1 (95% CI: 27.0-35.3) in females. There were 646 incident cases in males and 370 in females. The age-adjusted incidence rate was 245.3 / 100,000 person-year (95% CI: 221.6-268.9) and 94.8 (95% CI: 83.0-106.6) in males and females, respectively.

CONCLUSION

The mortality rate of stomach cancer in the JACC Study was lower than that in the vital statistics in Japan. Similar incidence rate of stomach cancer seems to be found between data of the JACC Study and that of the Research Group for Population-based Cancer Registration, but care is needed to interpret this similarity, because it might be due to different degree of completeness of incidence survey between the 2 studies.

摘要

背景

本研究的目的是调查日本协作队列研究（JACC研究）中胃癌的死亡率和发病率，并将其与日本普通人群的死亡率和发病率进行比较。

方法

该队列研究涉及居住在日本45个市町村的127,477人。通过死亡证明确定胃癌死亡情况。根据所有研究地区基线时年龄在40至79岁之间的110,792名受试者计算每10万人的年龄调整死亡率。发病病例定义为在癌症发病率调查观察期内患胃癌或死于胃癌的受试者。在有癌症登记处的24个研究市町村，对基线时年龄在40 - 79岁的64,820人确定并计算每10万人的年龄调整发病率。然后，将死亡率与1995年日本生命统计中公布的死亡率数据进行比较，将发病率与1992年日本人群癌症登记研究组公布的发病率数据进行比较。

结果

在超过10年的随访期间，有582例男性因胃癌死亡，287例女性因胃癌死亡。男性的年龄调整死亡率为93.4/10万人年（95%置信区间[CI]：84.6 - 102.2），女性为31.1（95%CI：27.0 - 35.3）。男性有646例发病病例，女性有370例。男性和女性的年龄调整发病率分别为245.3/10万人年（95%CI：221.6 - 268.9）和94.8（95%CI：83.0 - 106.6）。