饮茶与日本成年人胃癌风险的关联：日本合作队列研究。
Association of tea consumption and the risk of gastric cancer in Japanese adults: the Japan Collaborative Cohort Study.
机构信息
Public Health, Department of Socia Medicine, Osaka University Graduate School of Medicine, Suita-shi, Osaka-fu, Japan.
Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minia, Minia, Egypt.
出版信息
BMJ Open. 2020 Oct 6;10(10):e038243. doi: 10.1136/bmjopen-2020-038243.
OBJECTIVE
To examine the possible relationship between tea consumption and risk of gastric cancer (GC) among Japanese men and women included in a large Japanese population-based study titled the Japan Collaborative Cohort (JACC) Study.
DESIGN
Prospective cohort study.
SETTING
A population-based cohort included subjects who were recruited from 24 areas of JACC Study, in which data regarding the incidence of cancer were available.
PARTICIPANTS
63 848 participants (26 025 men and 37 823 women), aged 40-79, were included in the analyses and underwent follow-up (median 13.3 years) prospectively in research on cancer incidence.
PRIMARY AND SECONDARY OUTCOME MEASURES
The primary outcome variable was the risk of GC according to the frequency intakes of total tea, green tea, black tea and oolong tea. The adjusted HRs for the risk of GC associated with tea consumption were calculated using the Cox proportional hazards model.
RESULTS
1494 cases of GC were detected (960 men and 534 women) during the follow-up period. The multivariable-adjusted HRs for the risk of GC in the highest versus lowest quintiles of total tea intake were 1.05 (0.83-1.33); p trend=0.50 in men, and 0.82 (0.60-1.12); p trend=0.45 in women. There was no association found between the consumption of green tea, black tea or oolong tea with the risk for GC in either gender.
CONCLUSIONS
In this large community-based prospective cohort study, tea consumption was not associated with the risk of GC in either gender.
目的
在一项名为日本协同队列研究（JACC 研究）的大型日本人群基础研究中，研究饮茶与日本男性和女性胃癌（GC）风险之间的可能关系。
设计
前瞻性队列研究。
设置
该人群基础队列包括 JACC 研究中 24 个地区招募的对象，这些地区提供了癌症发病率的数据。
参与者
纳入了 63848 名参与者（26025 名男性和 37823 名女性），年龄在 40-79 岁之间，在癌症发病率的研究中进行了前瞻性随访（中位随访时间为 13.3 年）。
主要和次要结局测量
主要结局变量是根据总茶、绿茶、红茶和乌龙茶摄入量的频率发生 GC 的风险。使用 Cox 比例风险模型计算与茶消费相关的 GC 风险的调整后 HR。
结果
在随访期间共检测到 1494 例 GC（960 例男性和 534 例女性）。多变量调整后，男性中总茶摄入量最高五分位与最低五分位相比，GC 风险的 HR 为 1.05（0.83-1.33）；p 趋势=0.50，女性中为 0.82（0.60-1.12）；p 趋势=0.45。在男性和女性中，绿茶、红茶或乌龙茶的消费与 GC 风险之间均无关联。
结论
在这项大型社区为基础的前瞻性队列研究中，茶的消费与男性和女性的 GC 风险无关。
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