Wang Li, Santaella Ricardo M, Booth Marc, Koch Douglas D
Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA.
J Cataract Refract Surg. 2005 Aug;31(8):1512-9. doi: 10.1016/j.jcrs.2004.01.048.
To analyze the distribution of human higher-order wavefront aberrations (3rd- to 6th-order) from the internal optics (WA(internal)) and the variations with age and to evaluate the degree of compensation that the internal optics provide for anterior corneal aberrations (WA(cornea)).
Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA.
With assumption of a simple model for the eye, the WA(internal) were obtained by direct subtraction of the WA(cornea) from the ocular aberrations (WA(eye)). The WA(eye) were measured using the WaveScan system (Visx, Inc.), and the WA(cornea) were computed from the topographic data (Humphrey Atlas) using the CTView program (Sarver and Associates, Inc.). In 144 eyes of 114 normal patients (age 20 to 69 years), WA(internal) were calculated for a 6.0 mm pupil and a compensation factor (CF) was computed, with positive values representing compensation of WA(cornea) by WA(internal) and negative values indicating that the internal surfaces add aberrations to those of the cornea.
There was wide individual variation in WA(internal). The mean coefficient for 4th-order spherical aberration (Z(4)(0)) was -0.145 microm +/-0.094 (SD) (95% confidence interval [CI], -0.160 to -0.130 microm); 95.1% of eyes had negative values. The mean root-mean-square value for HOAs was 0.334 +/- 0.096 microm (95% CI, 0.319 to 0.350 microm). Moderate to high correlations were found between the right and left eyes in HOAs, 4th-order and 6th-order spherical aberration coefficients (Z(4)(0) and Z(6)(0)). With increasing age, the HOAs did not change, whereas the negative coefficients for Z(4)(0) tended to become less negative. Only the term Z(4)(0) had a CF significantly correlated with increasing age (r=-0.338, P<.05 with Bonferroni correction).
WA(internal) varied widely among patients, and a moderate to high degree of mirror symmetry existed between the right and left eyes. Internal surfaces compensated at least partially for the HOA and Z(4)(0) in most eyes, and this compensation decreased only mildly with increasing age.
分析来自眼内光学系统的人眼高阶像差（3至6阶）的分布情况及其随年龄的变化，并评估眼内光学系统对角膜前表面像差（WA(角膜)）的补偿程度。
美国得克萨斯州休斯顿贝勒医学院卡伦眼科研究所。
假设眼睛为简单模型，通过从全眼像差（WA(眼)）中直接减去WA(角膜)来获得WA(眼内)。使用WaveScan系统（威视公司）测量WA(眼)，并使用CTView程序（萨弗及合伙人公司）根据地形图数据（汉弗莱地图集）计算WA(角膜)。在114名正常患者（年龄20至69岁）的144只眼中，计算了6.0毫米瞳孔直径下的WA(眼内)，并计算了补偿因子（CF），正值表示WA(眼内)对WA(角膜)的补偿，负值表示眼内表面增加了角膜的像差。
WA(眼内)存在广泛的个体差异。四阶球差（Z(4)(0)）的平均系数为-0.145微米±0.094（标准差）（95%置信区间[CI]，-0.160至-0.130微米）；95.1%的眼睛为负值。高阶像差的平均均方根值为0.334±0.096微米（95%CI，0.319至0.350微米）。在高阶像差、四阶和六阶球差系数（Z(4)(0)和Z(6)(0)）方面，右眼和左眼之间存在中度至高度相关性。随着年龄增长，高阶像差没有变化，而Z(4)(0)的负系数趋于减小。只有Z(4)(0)项的CF与年龄增长显著相关（r=-0.338，经邦费罗尼校正后P<0.05）。
患者之间的WA(眼内)差异很大，左右眼之间存在中度至高度的镜像对称性。在大多数眼中，眼内表面至少部分补偿了高阶像差和Z(4)(0)，并且这种补偿仅随着年龄增长略有下降。
