母乳脂肪酸组成与婴儿特应性皮炎的发生有关。

Breast milk fatty acid composition is associated with development of atopic dermatitis in the infant.

作者信息

Hoppu Ulla, Rinne Minna, Lampi Anna-Maija, Isolauri Erika

机构信息

Department of Pediatrics, University of Turku, Finland.

出版信息

J Pediatr Gastroenterol Nutr. 2005 Sep;41(3):335-8. doi: 10.1097/01.mpg.0000168992.44428.fa.

DOI:10.1097/01.mpg.0000168992.44428.fa

PMID:16131990

Abstract

OBJECTIVE

Breast milk fatty acids may have immunomodulatory properties related to the development of atopic disease. The aim of this study was to assess the impact of the breast milk fatty acid composition on the development of atopic dermatitis (AD) in high-risk infants.

METHODS

Mothers with atopic disease were recruited at the end of gestation. Maternal food records and breast milk samples were collected at the infants' age of one month. Infants were clinically examined and AD diagnosed at one, three, six, and 12 months.

RESULTS

Altogether 13 of 34 (38%) infants were diagnosed with AD during the first year of life. Infants developing AD had consumed breast milk with a higher ratio of saturated to polyunsaturated fatty acids and less n-3 fatty acids compared to infants not developing AD. Specifically, breast milk consumed by infants with AD contained more stearic acid, 8.9% of total fatty acids (95% confidence interval 7.9-10.0) in comparison to those without AD, 7.1% (95% CI 6.6-7.7).

CONCLUSION

Breast milk rich in saturated and low in n-3 fatty acids may be a risk factor for atopic dermatitis in the infant.

摘要

目的

母乳中的脂肪酸可能具有与特应性疾病发展相关的免疫调节特性。本研究旨在评估母乳脂肪酸组成对高危婴儿特应性皮炎（AD）发展的影响。

方法

在妊娠末期招募患有特应性疾病的母亲。在婴儿1个月大时收集母亲的饮食记录和母乳样本。在1、3、6和12个月时对婴儿进行临床检查并诊断是否患有AD。

结果

在生命的第一年，34名婴儿中有13名（38%）被诊断患有AD。与未患AD的婴儿相比，患AD的婴儿摄入的母乳中饱和脂肪酸与多不饱和脂肪酸的比例更高，n-3脂肪酸含量更低。具体而言，患AD的婴儿所摄入的母乳中硬脂酸含量更高，占总脂肪酸的8.9%（95%置信区间7.9 - 10.0），而未患AD的婴儿为7.1%（95%置信区间6.6 - 7.7）。