Lehtimäki Terho, Ojala Petri, Rontu Riikka, Goebeler Sirkka, Karhunen Pekka J, Jylhä Marja, Mattila Kari, Metso Saara, Jokela Hannu, Nikkilä Matti, Wuolijoki Erkki, Hervonen Antti, Hurme Mikko
Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Tampere, Finland.
J Am Geriatr Soc. 2005 Sep;53(9):1552-8. doi: 10.1111/j.1532-5415.2005.53484.x.
To establish whether the relationship between interleukin-6 (IL-6) and plasma lipid and C-reactive protein (CRP) concentrations is different in Finnish nonagenarians than in middle-aged subjects with lower inflammatory status.
Cross-sectional.
Observational cohort study concentrating on the oldest old.
Nonagenarians (n=291, mean age+/-standard deviation 90+/-1; 68 men, 223 women) who lived in the Tampere municipality in southern Finland and a middle-aged control population from the same area (n=227, aged 44+/-8).
Plasma high sensitive CRP and lipid concentrations were analyzed using an automatic analyzer and IL-6 levels using enzyme-linked immunosorbent assay.
Plasma concentrations of IL-6 (4.39+/-5.25 vs 1.88+/-1.98 pg/mL) and CRP (3.54+/-4.98 vs 1.53+/-1.91 mg/L) were significantly higher in nonagenarians than in middle-aged subjects (P<.001). In nonagenarians, plasma CRP levels increased (P<.001) and plasma total cholesterol (P=.006), low-density lipoprotein cholesterol (P=.02), and high-density lipoprotein cholesterol (P=.002) levels decreased according to IL-6 quartiles. In middle-aged subjects, similar associations were not found.
The relationship between IL-6 and plasma CRP and cholesterol levels in nonagenarians with enhanced systemic inflammation differs from that of middle-aged subjects.
确定芬兰百岁老人中白细胞介素-6（IL-6）与血脂及C反应蛋白（CRP）浓度之间的关系是否与炎症状态较低的中年受试者不同。
横断面研究。
针对高龄老人的观察性队列研究。
居住在芬兰南部坦佩雷市的百岁老人（n = 291，平均年龄±标准差90±1岁；68名男性，223名女性）以及来自同一地区的中年对照人群（n = 227，年龄44±8岁）。
使用自动分析仪分析血浆高敏CRP和血脂浓度，使用酶联免疫吸附测定法检测IL-6水平。
百岁老人的血浆IL-6浓度（4.39±5.25 vs 1.88±1.98 pg/mL）和CRP浓度（3.54±4.98 vs 1.53±1.91 mg/L）显著高于中年受试者（P <.001）。在百岁老人中，根据IL-6四分位数，血浆CRP水平升高（P <.001），血浆总胆固醇（P =.006）、低密度脂蛋白胆固醇（P =.02）和高密度脂蛋白胆固醇（P =.002）水平降低。在中年受试者中未发现类似关联。
全身炎症增强的百岁老人中IL-6与血浆CRP和胆固醇水平之间的关系与中年受试者不同。
