中非共和国艾滋病相关卡波西肉瘤患者的人疱疹病毒8血清学标志物与病毒载量
Human herpesvirus 8 serological markers and viral load in patients with AIDS-associated Kaposi's sarcoma in Central African Republic.
作者信息
Duprez Renan, Kassa-Kelembho Eric, Plancoulaine Sabine, Brière Josette, Fossi Mireille, Kobangue Léon, Minsart Pierre, Huerre Michel, Gessain Antoine
机构信息
Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département Ecosytèmes et Epidémiologie des Maladies Infectieuses. Batiment Lwoff., Institut Pasteur, Paris, France.
出版信息
J Clin Microbiol. 2005 Sep;43(9):4840-3. doi: 10.1128/JCM.43.9.4840-4843.2005.
Abstract
Epidemic Kaposi's sarcoma (KS) is one of the most frequent types of cancer in several African countries; however, very few data are available on human herpesvirus 8 (HHV-8) markers in KS patients from Central Africa. In a series of 36 AIDS-KS cases from Central African Republic, we showed, using a real-time PCR quantitative assay, the high frequency (82%) of detectable HHV-8 DNA in peripheral blood mononuclear cells (PBMCs). We also found that the level of antibodies directed against lytic or latent HHV-8 antigens is not correlated to the amount of HHV-8 viral load in the PBMCs, and finally, we demonstrated a much higher viral load in tumoral skin lesions (6.07 log copies/mug DNA) than in unaffected skin (2.93 log copies/mug DNA) or in PBMCs (2.55 log copies/mug DNA).
摘要
流行性卡波西肉瘤（KS）是几个非洲国家最常见的癌症类型之一；然而，关于中非KS患者中人类疱疹病毒8型（HHV-8）标志物的数据非常少。在一系列来自中非共和国的36例艾滋病相关KS病例中，我们使用实时PCR定量检测方法显示，外周血单个核细胞（PBMC）中可检测到HHV-8 DNA的频率很高（82%）。我们还发现，针对HHV-8裂解或潜伏抗原的抗体水平与PBMC中HHV-8病毒载量无关，最后，我们证明肿瘤皮肤病变中的病毒载量（6.07 log拷贝/μg DNA）比未受影响的皮肤（2.93 log拷贝/μg DNA）或PBMC（2.55 log拷贝/μg DNA）高得多。
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