Pitsavos Christos, Panagiotakos Demosthenes B, Tzima Natalia, Chrysohoou Christina, Economou Manolis, Zampelas Antonis, Stefanadis Christodoulos
First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
Am J Clin Nutr. 2005 Sep;82(3):694-9. doi: 10.1093/ajcn.82.3.694.
Greater adherence to the Mediterranean diet has been associated with a lower incidence of cardiovascular disease and cancer.
We studied the effect of the Mediterranean diet on total antioxidant capacity (TAC) in 3042 participants who had no clinical evidence of cardiovascular disease.
During 2001-2002, a random sample of 1514 men and 1528 women aged 18-89 y from the Attica area of Greece was selected. TAC was measured with an immune-diagnostic assay. Food consumption was evaluated with a validated food-frequency questionnaire, and adherence to the Mediterranean diet was assessed on the basis of a diet score that incorporated the inherent characteristics of this diet.
TAC was positively correlated with diet score. The participants in the highest tertile of the diet score had, on average, 11% higher TAC levels than did the participants in the lowest tertile, even after adjustment for relevant confounders (P < 0.01). On the other hand, the participants in the highest tertile of the diet score had, on average, 19% lower oxidized LDL-cholesterol concentrations than did the participants in the lowest tertile (P < 0.01). An additional analysis showed that TAC was positively correlated with the consumption of olive oil (rho = 0.54, P = 0.002) and of fruit and vegetables (rho = 0.34 and rho = 0.31, respectively; P < 0.001 for both), whereas it was inversely associated with the consumption of red meat (rho = -0.35, P = 0.02).
Greater adherence to the Mediterranean diet is associated with elevated TAC levels and low oxidized LDL-cholesterol concentrations, which may explain the beneficial role of this diet on the cardiovascular system.
对地中海饮食依从性更高与心血管疾病和癌症的较低发病率相关。
我们研究了地中海饮食对3042名无心血管疾病临床证据参与者的总抗氧化能力（TAC）的影响。
在2001年至2002年期间，从希腊阿提卡地区随机抽取了1514名年龄在18 - 89岁的男性和1528名女性。用免疫诊断测定法测量TAC。通过一份经验证的食物频率问卷评估食物摄入量，并根据纳入该饮食固有特征的饮食评分评估对地中海饮食的依从性。
TAC与饮食评分呈正相关。即使在对相关混杂因素进行调整后，饮食评分处于最高三分位数的参与者的TAC水平平均比处于最低三分位数的参与者高11%（P < 0.01）。另一方面，饮食评分处于最高三分位数的参与者的氧化型低密度脂蛋白胆固醇浓度平均比处于最低三分位数的参与者低19%（P < 0.01）。进一步分析表明，TAC与橄榄油（rho = 0.54，P = 0.002）以及水果和蔬菜（rho分别为0.34和0.31；两者P均< 0.001）的摄入量呈正相关，而与红肉摄入量呈负相关（rho = -0.35，P = 0.02）。
对地中海饮食依从性更高与TAC水平升高和氧化型低密度脂蛋白胆固醇浓度降低相关，这可能解释了这种饮食对心血管系统的有益作用。
