Brenner D E, Gescher A J
Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan & VA Medical Center, Ann Arbor, 48109, 0930, USA.
Br J Cancer. 2005 Oct 3;93(7):735-9. doi: 10.1038/sj.bjc.6602765.
The concept of delaying or preventing epithelial transformation remains a viable and attainable goal for the future. Drug-based strategies for chemoprevention of the future may predominantly rely upon targeted therapies with tolerable but defined toxicities for treatment of individuals diagnosed with intraepithelial neoplasias. Foods, diet manipulation strategies, or nutraceuticals may be more appropriate to delay or prevent carcinogenesis progression in healthy populations with genetic or epidemiologic evidence of risk for future transformation.
延迟或预防上皮化生的概念仍是未来一个可行且可实现的目标。未来基于药物的化学预防策略可能主要依赖于靶向治疗，这种治疗对诊断为上皮内瘤变的个体具有可耐受但明确的毒性。对于有未来化生风险的遗传或流行病学证据的健康人群，食物、饮食调控策略或营养保健品可能更适合延迟或预防癌症进展。
